{"id":"W2086592453","doi":"10.1007/s10719-010-9302-5","title":"Thymoquinone-induced Neu4 sialidase activates NFκB in macrophage cells and pro-inflammatory cytokines in vivo","year":2010,"lang":"en","type":"article","venue":"Glycoconjugate Journal","topic":"Nigella sativa pharmacological applications","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hotchkiss Brain Institute; Queen's University; University of Calgary","funders":"","keywords":"Chemistry; TLR4; HEK 293 cells; Molecular biology; Cell biology; Signal transduction; Receptor; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0005831246,0.0002688695,0.0004381453,0.0003169138,0.0001300045,0.00008716706,0.0001814123,0.0002175566,0.001037226],"category_scores_gemma":[0.0001414821,0.0002118718,0.00007865814,0.0003342904,0.0001424673,0.000253643,0.00009588931,0.001681741,0.00005023834],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009937376,"about_ca_system_score_gemma":0.0001754697,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003341984,"about_ca_topic_score_gemma":0.00007694236,"domain_scores_codex":[0.9981309,0.0001134698,0.0006394315,0.0003495608,0.0002707509,0.0004958821],"domain_scores_gemma":[0.9988177,0.0002034739,0.0002202682,0.0002418742,0.00009985878,0.0004167683],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003407592,0.0002280377,0.01579252,0.00004259151,0.00001957778,0.0008909059,0.000350834,0.000004763956,0.9792001,0.0001108992,0.0002853441,0.002733674],"study_design_scores_gemma":[0.004754832,0.0002224213,0.05357647,0.00009320338,0.00003733926,0.001074257,0.0001673941,0.0001860281,0.9315863,0.001000838,0.007025842,0.0002751207],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950442,0.00005484491,0.0000103523,0.002019104,0.0002906754,0.000915897,0.0000100922,0.00004701693,0.001607836],"genre_scores_gemma":[0.997569,0.000141423,0.0009581681,0.0004807778,0.0004853403,0.00005977551,0.000002011531,0.00003432706,0.000269159],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04761384,"threshold_uncertainty_score":0.999876,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01565286837586786,"score_gpt":0.2918416730995923,"score_spread":0.2761888047237244,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}