{"id":"W2086599553","doi":"10.1371/journal.ppat.1000331","title":"Enhanced Fusion Pore Expansion Mediated by the Trans-Acting Endodomain of the Reovirus FAST Proteins","year":2009,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Canadian Institutes of Health Research; Shanghai Ocean University; Nova Scotia Health Research Foundation","keywords":"Cell biology; Fusion protein; Transmembrane protein; Biology; Cytoplasm; Transfection; Membrane protein; Cytosol; Lipid bilayer fusion; Transmembrane domain; Cell fusion; Cell; Biochemistry; Membrane; Gene; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002121969,0.0003141437,0.0001477083,0.0001392877,0.00009112325,0.0002611776,0.0001735529,0.0002957526,0.0008382677],"category_scores_gemma":[0.0001358933,0.0001195197,0.0002739958,0.00007119014,0.0002493766,0.0002688409,0.0004309371,0.0004899626,0.0003009628],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002878269,"about_ca_system_score_gemma":0.0001796897,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002122076,"about_ca_topic_score_gemma":0.0002866969,"domain_scores_codex":[0.9998573,0.00003138985,0.00001035056,0.00002570442,0.00003718384,0.00003798477],"domain_scores_gemma":[0.9998732,0.00003808338,0.00003483148,0.00001735773,0.00001203113,0.00002450972],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002843908,0.000004963271,0.00004231929,0.000009183429,0.000001358739,0.00002798455,0.000006694116,0.00003738859,0.9994226,0.0001355918,0.000006328102,0.0002771927],"study_design_scores_gemma":[0.00001074723,0.0001179493,0.000990503,0.000002691037,0.000005717238,0.0002449258,0.00001873681,0.0007607864,0.9966285,0.00005365993,0.001163029,0.000002808232],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944448,0.0004104974,0.004188807,0.00004236405,0.00001333356,0.00001532582,0.00008420511,0.00003753974,0.0007631939],"genre_scores_gemma":[0.9953759,0.0002616986,0.003049687,0.00002004208,0.000003476174,0.00001226484,0.0001493603,0.00002164467,0.001106018],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008382677,"threshold_uncertainty_score":0.002804339,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01656047322397555,"score_gpt":0.2610711082707145,"score_spread":0.2445106350467389,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}