{"id":"W2086662350","doi":"10.1021/bi050472w","title":"Crystal Structure of <i>Methanobacterium thermoautotrophicum</i> Phosphoribosyl-AMP Cyclohydrolase HisI<sup>,</sup>","year":2005,"lang":"en","type":"article","venue":"Biochemistry","topic":"Enzyme Structure and Function","field":"Materials Science","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Biotechnology Research Institute","funders":"National Institute of General Medical Sciences","keywords":"Aquifex aeolicus; Chemistry; Dimer; Stereochemistry; Histidine; Binding site; Active site; Enzyme; Monomer; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001234764,0.0003008501,0.0003126633,0.00003974621,0.0001416163,0.00004300304,0.0004063662,0.0003131456,0.003023665],"category_scores_gemma":[0.00006944541,0.0002614444,0.0001357533,0.000182401,0.0001731074,0.0001657968,0.0002127562,0.0002084406,0.00005140419],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009063288,"about_ca_system_score_gemma":0.00008937151,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000429975,"about_ca_topic_score_gemma":0.000005379808,"domain_scores_codex":[0.9982732,0.00003786704,0.0004097124,0.0004883372,0.0004041237,0.0003867444],"domain_scores_gemma":[0.9988338,0.00003580061,0.0002231483,0.0006456913,0.0001154086,0.0001460901],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001005424,0.00003871315,0.0001861502,0.00007730459,0.00001562724,0.000002569594,0.0002411547,0.0003390149,0.9963713,0.00002285903,0.00195942,0.0006452925],"study_design_scores_gemma":[0.000428517,0.00003668618,0.0002501955,0.00002741232,0.00003534215,0.00005207653,0.00003876771,0.0001258131,0.9927483,0.0001749806,0.005807773,0.0002741354],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969867,0.0004452098,0.0001326347,0.000124163,0.0002976637,0.0001064491,0.0002832571,0.0001186881,0.001505173],"genre_scores_gemma":[0.9958293,0.00001648388,0.002114153,0.0001851734,0.0009911389,0.000005270445,0.00009340054,0.00003409094,0.0007309406],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003848353,"threshold_uncertainty_score":0.9999838,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00529479959180286,"score_gpt":0.2070293554792034,"score_spread":0.2017345558874005,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}