{"id":"W2086663462","doi":"10.1038/nature09871","title":"Copy number variation and selection during reprogramming to pluripotency","year":2011,"lang":"en","type":"article","venue":"Nature","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":949,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children; University of Toronto; Ontario Institute for Cancer Research; Lunenfeld-Tanenbaum Research Institute","funders":"","keywords":"Reprogramming; Induced pluripotent stem cell; Biology; Copy-number variation; Embryonic stem cell; Somatic cell; Genetics; Cell biology; Cell; Genome; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005258682,0.0001687218,0.0002503326,0.0004694059,0.0002301619,0.0007564281,0.0005703502,0.0003406191,0.001536297],"category_scores_gemma":[0.001300415,0.0003062314,0.0002078399,0.0004045046,0.0003400205,0.0005199047,0.000611692,0.0007045325,0.0004634221],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005675561,"about_ca_system_score_gemma":0.000212133,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000635306,"about_ca_topic_score_gemma":0.002180075,"domain_scores_codex":[0.9993481,0.0001414973,0.00004816524,0.0001343411,0.0002392359,0.00008876296],"domain_scores_gemma":[0.9992825,0.000377579,0.0001097331,0.0001008673,0.00006209006,0.00006723353],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007746398,0.000008636083,0.001640888,0.000008546736,0.000006236346,0.00007341589,0.00003107332,0.0002671966,0.991935,0.000499468,0.00004555636,0.005406456],"study_design_scores_gemma":[0.00001420017,0.0001402606,0.02624013,0.0000064853,0.00002764992,0.0009610197,0.00007443618,0.007658619,0.9608069,0.0009180891,0.00312168,0.00003060018],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9864922,0.0005410882,0.009687152,0.0001425815,0.00002334681,0.00002039871,0.0001911892,0.00009281811,0.002809177],"genre_scores_gemma":[0.9933299,0.0002747331,0.003224184,0.00008111389,0.00001225915,0.00001653193,0.0002428438,0.0001663083,0.002651951],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001536297,"threshold_uncertainty_score":0.00513947,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008863039891250939,"score_gpt":0.2643158256502704,"score_spread":0.2554527857590195,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}