{"id":"W2086673145","doi":"10.1097/tp.0b013e3181fed001","title":"Regulatory T-Cell Generation and Kidney Allograft Tolerance Induced by Mesenchymal Stem Cells Associated With Indoleamine 2,3-Dioxygenase Expression","year":2010,"lang":"en","type":"article","venue":"Transplantation","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":353,"is_retracted":false,"has_abstract":true,"ca_institutions":"London Health Sciences Centre; Lawson Health Research Institute; Western University","funders":"","keywords":"Indoleamine 2,3-dioxygenase; Mesenchymal stem cell; FOXP3; Immune tolerance; IL-2 receptor; Immunology; Immunosuppression; Medicine; Kidney; In vivo; Transplantation; Spleen; Kynurenine; Regulatory T cell; T cell; Cancer research; Immune system; Biology; Endocrinology; Internal medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000198357,0.0003672279,0.000222737,0.000226476,0.00009219588,0.0002025732,0.0001503182,0.0002136012,0.0008822158],"category_scores_gemma":[0.0001045754,0.00008789371,0.0002875222,0.0001131598,0.0002628759,0.0001215668,0.0001734467,0.0004468349,0.0001996334],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001315657,"about_ca_system_score_gemma":0.0001738747,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001075012,"about_ca_topic_score_gemma":0.0001523859,"domain_scores_codex":[0.9998209,0.00002838445,0.00002014395,0.0000288514,0.00005479067,0.00004694282],"domain_scores_gemma":[0.9998822,0.00001352182,0.00005116745,0.00001158715,0.00001096307,0.00003056566],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002367837,0.00005741072,0.0005675134,0.00005993964,0.000005839937,0.0001213476,0.0000220298,0.0000505424,0.9971948,0.0001276355,0.00002115123,0.0015351],"study_design_scores_gemma":[0.00007230457,0.001334426,0.008824093,0.0000127972,0.00006402929,0.0008673765,0.00004775086,0.001053362,0.9859951,0.0001125691,0.001611057,0.000005142232],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957211,0.00129508,0.002126699,0.00003199844,0.0000235038,0.0000286103,0.00007232923,0.00003621758,0.0006644612],"genre_scores_gemma":[0.9980159,0.0004210917,0.0007615183,0.00002449024,0.00001233235,0.00002956283,0.0001548333,0.000005172383,0.0005750878],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008822158,"threshold_uncertainty_score":0.002951264,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01473205923068548,"score_gpt":0.2134261338317392,"score_spread":0.1986940746010537,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}