{"id":"W2086673145","doi":"10.1097/tp.0b013e3181fed001","title":"Regulatory T-Cell Generation and Kidney Allograft Tolerance Induced by Mesenchymal Stem Cells Associated With Indoleamine 2,3-Dioxygenase Expression","year":2010,"lang":"en","type":"article","venue":"Transplantation","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":353,"is_retracted":false,"has_abstract":true,"ca_institutions":"London Health Sciences Centre; Lawson Health Research Institute; Western University","funders":"","keywords":"Indoleamine 2,3-dioxygenase; Mesenchymal stem cell; FOXP3; Immune tolerance; IL-2 receptor; Immunology; Immunosuppression; Medicine; Kidney; In vivo; Transplantation; Spleen; Kynurenine; Regulatory T cell; T cell; Cancer research; Immune system; Biology; Endocrinology; Internal medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001175667,0.0001800775,0.000135914,0.00007005913,0.0001685362,0.00005866991,0.0001053222,0.0001491862,0.00002952991],"category_scores_gemma":[0.00001605846,0.0001555674,0.00002404734,0.0001747675,0.00007557638,0.0003153458,0.000005776468,0.0002329033,0.000005349342],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000111052,"about_ca_system_score_gemma":0.00004294173,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008868597,"about_ca_topic_score_gemma":0.00006868973,"domain_scores_codex":[0.998768,0.0001201919,0.0001898428,0.0004126887,0.0002905692,0.0002187202],"domain_scores_gemma":[0.9994696,0.00008209946,0.0001156255,0.0001535141,0.00002962458,0.0001495867],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009884721,0.0001028632,0.0002098397,0.00003443033,0.000002336235,0.000008586592,0.0006181882,0.00002431942,0.9981323,0.00002805462,0.0003381547,0.000402041],"study_design_scores_gemma":[0.002086234,0.0001079467,0.003557472,0.00003809098,0.000007700488,0.000007295727,0.00002730097,0.0009258991,0.9928824,0.000006051698,0.0001420609,0.0002116033],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982933,0.0000194849,0.0006471201,0.00007022088,0.0001715614,0.0003082635,0.0001205783,0.0001027776,0.0002666796],"genre_scores_gemma":[0.9988931,0.00005939013,0.0001657082,0.0004522005,0.00004525419,0.00002314905,0.0001075638,0.00002430894,0.000229292],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005249995,"threshold_uncertainty_score":0.6343855,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01473205923068548,"score_gpt":0.2134261338317392,"score_spread":0.1986940746010537,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}