{"id":"W2086697658","doi":"10.1016/j.neurobiolaging.2013.07.010","title":"Selective benefits of simvastatin in bitransgenic APPSwe,Ind/TGF-β1 mice","year":2013,"lang":"en","type":"article","venue":"Neurobiology of Aging","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"Montreal Neurological Institute and Hospital; McGill University","funders":"Canadian Institutes of Health Research; National Institutes of Health; Gladstone Institutes","keywords":"Simvastatin; Amyloid precursor protein; Neprilysin; Medicine; Internal medicine; Endocrinology; Stimulation; Agonist; Pharmacology; Alzheimer's disease; Chemistry; Disease; Biochemistry; Enzyme; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003082684,0.001221495,0.0008365418,0.001246525,0.0005060397,0.0006980611,0.0005655311,0.001197961,0.003486332],"category_scores_gemma":[0.0002748343,0.0003942371,0.0006874868,0.0005519513,0.001012616,0.0009675872,0.0004100927,0.002093821,0.0008601238],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003842285,"about_ca_system_score_gemma":0.0005796317,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001264415,"about_ca_topic_score_gemma":0.00225118,"domain_scores_codex":[0.9995797,0.00004435514,0.00006478906,0.00009759625,0.00007898846,0.0001344812],"domain_scores_gemma":[0.999182,0.00007980924,0.0002540569,0.00009375495,0.00006823667,0.0003220023],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004764721,0.0002300107,0.0002602753,0.00005512155,0.00001866701,0.0002111957,0.00003944562,0.00004967441,0.9924095,0.0002565749,0.00009998504,0.001604772],"study_design_scores_gemma":[0.0006008794,0.00177819,0.005870423,0.00002193387,0.0001776985,0.000539773,0.0002107476,0.0005579269,0.9873448,0.0003720341,0.002494349,0.00003114649],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931799,0.001252767,0.00127359,0.0003728498,0.0001668495,0.00005082878,0.001913585,0.0002369388,0.001552681],"genre_scores_gemma":[0.9839364,0.001861162,0.002234909,0.0001994453,0.0001017575,0.0001567699,0.00141659,0.0001750166,0.00991792],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003486332,"threshold_uncertainty_score":0.01166296,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02073493994495553,"score_gpt":0.2870187549077202,"score_spread":0.2662838149627647,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}