{"id":"W2086714780","doi":"10.1172/jci59755","title":"The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation","year":2012,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Drug-Induced Hepatotoxicity and Protection","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":763,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Environmental Health Sciences; McGill University; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute on Alcohol Abuse and Alcoholism; National Institutes of Health; National Center for Research Resources; National Institute of General Medical Sciences","keywords":"Acetaminophen; DNA fragmentation; Fragmentation (computing); Mitochondrial DNA; Nuclear DNA; Toxicity; Apoptosis; DNA damage; Programmed cell death; Glutamate dehydrogenase; Mitochondrial toxicity; Mitochondrion; Liver injury; Biology; Pharmacology; Internal medicine; Medicine; Glutamate receptor; DNA; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002269958,0.0006508019,0.0001824499,0.0004999192,0.0002165806,0.0002342504,0.0001785523,0.0003711625,0.001847622],"category_scores_gemma":[0.0001543984,0.0001597149,0.0002830847,0.000241036,0.0004062875,0.000312175,0.0002806765,0.00051381,0.000249663],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002562245,"about_ca_system_score_gemma":0.0002248027,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004909034,"about_ca_topic_score_gemma":0.0006678798,"domain_scores_codex":[0.9998103,0.00005566214,0.00001468435,0.00004031439,0.00005477096,0.00002423214],"domain_scores_gemma":[0.999896,0.000008880134,0.00005557663,0.00001216728,0.00001262333,0.00001474197],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001686088,0.0003356519,0.008543983,0.0003506618,0.0001170355,0.0007130909,0.0001015773,0.0001915345,0.9643702,0.0006851025,0.0003807621,0.02252436],"study_design_scores_gemma":[0.0002215746,0.008078218,0.1540072,0.000152361,0.0001991336,0.007350014,0.0002882793,0.001879704,0.8120699,0.001011543,0.01469728,0.00004481699],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9648548,0.0130214,0.01610594,0.0006418402,0.00009118678,0.0003337488,0.0006924302,0.0001645059,0.004094112],"genre_scores_gemma":[0.9886691,0.005157498,0.003533777,0.0002426413,0.0000214792,0.0001579018,0.0003830102,0.000006631949,0.001828015],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001847622,"threshold_uncertainty_score":0.006180942,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3241631573058402,"score_gpt":0.48222312165209,"score_spread":0.1580599643462498,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}