{"id":"W2086736202","doi":"10.1111/j.1471-4159.2004.02488.x","title":"Developmental differences in H<sub>2</sub>O<sub>2</sub>‐induced oligodendrocyte cell death: role of glutathione, mitogen‐activated protein kinases and caspase 3","year":2004,"lang":"en","type":"article","venue":"Journal of Neurochemistry","topic":"Sulfur Compounds in Biology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":82,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; McGill University","funders":"Canadian Institutes of Health Research; Multiple Sclerosis Society of Canada","keywords":"MAPK/ERK pathway; Oligodendrocyte; Kinase; p38 mitogen-activated protein kinases; Glutathione; DNA fragmentation; Programmed cell death; Molecular biology; Protein kinase A; Biology; Apoptosis; Cell biology; Caspase; Caspase 3; Biochemistry; Chemistry; Myelin; Enzyme; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002297486,0.0004814749,0.0004513003,0.0004955806,0.0001789979,0.0004162177,0.0002293455,0.0004394295,0.001251622],"category_scores_gemma":[0.0002315599,0.0003428547,0.0004407613,0.0002478881,0.0003663474,0.0004327884,0.0003133508,0.0006379508,0.0003016338],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004711403,"about_ca_system_score_gemma":0.000308123,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001111753,"about_ca_topic_score_gemma":0.002261456,"domain_scores_codex":[0.9998185,0.00001823846,0.00003040458,0.00004026635,0.00004694481,0.00004572397],"domain_scores_gemma":[0.999712,0.00003460141,0.0001008704,0.00001979929,0.00005161026,0.00008108043],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002687266,0.00001815572,0.0002728606,0.00003710799,0.000006939866,0.00008406922,0.00004100514,0.00001305146,0.9986745,0.00005004897,0.00001224866,0.0005214372],"study_design_scores_gemma":[0.00001987058,0.0005134905,0.03125902,0.00001023683,0.00004324776,0.0003714166,0.0001063997,0.0002867241,0.9659998,0.00008919376,0.001288347,0.00001209252],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9900677,0.003520532,0.00368097,0.00006789667,0.00003924105,0.0001132584,0.0009055125,0.00009964634,0.001505244],"genre_scores_gemma":[0.9876927,0.002816709,0.00366267,0.0001011599,0.00001596685,0.0003074736,0.001169659,0.00005207435,0.004181437],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001251622,"threshold_uncertainty_score":0.004187047,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01268639480316329,"score_gpt":0.2168935146636493,"score_spread":0.204207119860486,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}