{"id":"W2086747295","doi":"10.1038/mtna.2013.66","title":"Influence of Polyethylene Glycol Lipid Desorption Rates on Pharmacokinetics and Pharmacodynamics of siRNA Lipid Nanoparticles","year":2013,"lang":"en","type":"article","venue":"Molecular Therapy — Nucleic Acids","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":482,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Acuitas Therapeutics (Canada)","funders":"","keywords":"Gene silencing; In vivo; Polyethylene glycol; PEG ratio; PEGylation; Chemistry; Gene knockdown; Pharmacokinetics; Biophysics; Gene delivery; Biodistribution; Lipid metabolism; Pharmacology; Biochemistry; Cell biology; In vitro; Genetic enhancement; Gene; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001106246,0.000225656,0.000226693,0.00007441119,0.00003983493,0.00002072282,0.0002497739,0.0001302823,0.00004916804],"category_scores_gemma":[0.0000243397,0.0002074218,0.00009783454,0.000120859,0.0001982598,0.00001517575,0.00008193462,0.0000960107,0.00001336005],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008908526,"about_ca_system_score_gemma":0.00003066738,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000444379,"about_ca_topic_score_gemma":0.000001433704,"domain_scores_codex":[0.9988213,0.00009297535,0.0003476575,0.0003164865,0.0001819592,0.0002396848],"domain_scores_gemma":[0.9991843,0.0000159627,0.0001762464,0.0003255584,0.0002072683,0.00009070481],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003033647,0.0001470177,0.002184871,0.00002651881,0.0001181835,0.000001692278,0.00008677684,0.001488876,0.9838378,0.00003063621,0.00008735553,0.01168693],"study_design_scores_gemma":[0.001097319,0.001141738,0.005836595,0.00003482412,0.00002413312,0.000006187086,0.00003633702,0.0007615775,0.9900619,0.00007511571,0.0007166041,0.0002076163],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980419,0.001093972,0.0002339707,0.0001287883,0.00006530913,0.0003344293,0.0000171631,0.00001204569,0.00007247118],"genre_scores_gemma":[0.9957904,0.002968446,0.0003219326,0.0007201079,0.00006427315,0.00003083445,0.0000213667,0.00003432609,0.00004834399],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01147932,"threshold_uncertainty_score":0.8458417,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00803909908987599,"score_gpt":0.2527792610581531,"score_spread":0.2447401619682771,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}