{"id":"W2086747295","doi":"10.1038/mtna.2013.66","title":"Influence of Polyethylene Glycol Lipid Desorption Rates on Pharmacokinetics and Pharmacodynamics of siRNA Lipid Nanoparticles","year":2013,"lang":"en","type":"article","venue":"Molecular Therapy — Nucleic Acids","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":482,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Acuitas Therapeutics (Canada)","funders":"","keywords":"Gene silencing; In vivo; Polyethylene glycol; PEG ratio; PEGylation; Chemistry; Gene knockdown; Pharmacokinetics; Biophysics; Gene delivery; Biodistribution; Lipid metabolism; Pharmacology; Biochemistry; Cell biology; In vitro; Genetic enhancement; Gene; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003704299,0.000272892,0.0001523473,0.0001174536,0.00007907294,0.0002465072,0.0001170198,0.0002041819,0.0004887913],"category_scores_gemma":[0.0009663486,0.0001827341,0.0001475565,0.00009357549,0.0001582645,0.0003119745,0.0001103723,0.0003326842,0.000257257],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002836804,"about_ca_system_score_gemma":0.0002287155,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008636523,"about_ca_topic_score_gemma":0.0005755743,"domain_scores_codex":[0.9998351,0.00004444406,0.00001532759,0.00003904201,0.00003429612,0.00003160163],"domain_scores_gemma":[0.9995215,0.0002649715,0.0001069091,0.00002290821,0.00005588938,0.00002789773],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005390038,0.0000346526,0.0006295336,0.00002733641,0.000008664462,0.0000347918,0.00004856511,0.0005682093,0.9950473,0.00004478707,0.00003655003,0.002980593],"study_design_scores_gemma":[0.000008822929,0.0004343628,0.001212432,0.000001961486,0.000009828589,0.0000240703,0.00001338647,0.00199228,0.9959401,0.00001689034,0.0003397767,0.000006040401],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965531,0.0005410519,0.002024069,0.00004553831,0.00001152276,0.0000193127,0.0001192054,0.00003307733,0.0006531541],"genre_scores_gemma":[0.9969093,0.0004437958,0.001657601,0.00004653288,0.000005459056,0.00003194351,0.0001013002,0.00003016274,0.0007738755],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008636523,"threshold_uncertainty_score":0.002058208,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00803909908987599,"score_gpt":0.2527792610581531,"score_spread":0.2447401619682771,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}