{"id":"W2086761335","doi":"10.1111/jnc.12792","title":"Desvenlafaxine prevents white matter injury and improves the decreased phosphorylation of the rate‐limiting enzyme of cholesterol synthesis in a chronic mouse model of depression","year":2014,"lang":"en","type":"article","venue":"Journal of Neurochemistry","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; University of Saskatchewan; University of Alberta","funders":"Canadian Institutes of Health Research; AstraZeneca Canada","keywords":"Limiting; Depression (economics); White matter; Enzyme; Internal medicine; Phosphorylation; Endocrinology; Medicine; Cholesterol; Chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002834311,0.0001066625,0.0002080758,0.00004266132,0.00003536939,0.00001120641,0.0003343714,0.00005465167,0.000007589686],"category_scores_gemma":[0.0007669894,0.00006564776,0.00008950706,0.0001136977,0.0001302524,0.0001132535,0.00008551143,0.0002040337,1.111517e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001908702,"about_ca_system_score_gemma":0.00006701704,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002565017,"about_ca_topic_score_gemma":8.901139e-7,"domain_scores_codex":[0.9988798,0.0001503796,0.0004877186,0.000135535,0.0002298716,0.0001166416],"domain_scores_gemma":[0.9985543,0.0003018374,0.0008324975,0.000228212,0.00004575427,0.00003740804],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001198164,0.00007143496,0.007312273,0.0001585607,0.000003549791,2.503703e-7,0.0001098205,0.001209658,0.9901921,8.334034e-7,0.00002047786,0.0008011818],"study_design_scores_gemma":[0.0004617687,0.00003841318,0.06558147,0.000256889,0.00001470544,0.00001009061,0.00002879777,0.008288361,0.925203,0.00006648828,0.000001847687,0.00004812942],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994887,0.00005235837,0.0001376506,0.0001369721,0.00002043949,0.00009020183,0.000007237369,0.000002035553,0.00006447268],"genre_scores_gemma":[0.9996963,0.00004104322,0.00004165938,0.0001455299,0.00001853541,0.000002847187,1.051752e-7,0.00001241932,0.00004154988],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0649891,"threshold_uncertainty_score":0.2677038,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01155769891370388,"score_gpt":0.2295273256134559,"score_spread":0.217969626699752,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}