{"id":"W2086786506","doi":"10.1530/endoabs.32.p845","title":"Pasireotide LAR and octreotide LAR maintain inhibition of GH and IGF1 in patients with acromegaly: 12-month extension phase of a randomized, double-blind, multicenter, phase III study","year":2013,"lang":"en","type":"article","venue":"Endocrine Abstracts","topic":"Pituitary Gland Disorders and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; Université de Montréal; Hôpital Notre-Dame","funders":"Novartis Pharmaceuticals Corporation","keywords":"Acromegaly; Pasireotide; Octreotide; Medicine; Double blind; Internal medicine; Phase (matter); Endocrinology; Somatostatin; Gastroenterology; Growth hormone; Chemistry; Pathology; Placebo","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002522106,0.000272322,0.0009435285,0.00025141,0.00004189369,0.00001487613,0.00003640173,0.00003368909,0.00004585413],"category_scores_gemma":[0.0001119418,0.0001760615,0.00007052799,0.0001114622,0.0001355562,0.0003200975,0.00005279297,0.0001274609,0.000002998876],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002757074,"about_ca_system_score_gemma":0.00002834574,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002170844,"about_ca_topic_score_gemma":0.0003372119,"domain_scores_codex":[0.9981812,0.00008182466,0.0007424532,0.0003700079,0.0003156158,0.0003088494],"domain_scores_gemma":[0.9988604,0.0001451893,0.0003933487,0.000263045,0.0001497186,0.0001882767],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6495125,0.02873773,0.3058412,0.0002162969,0.000615327,0.0007463034,0.0007694835,0.00001021142,0.001733522,0.0000297323,0.0000456202,0.01174201],"study_design_scores_gemma":[0.7981493,0.003415364,0.19397,0.0002945584,0.0003194199,0.00001674189,0.0004513997,0.0000359866,0.0030961,0.0001012507,0.000009351439,0.0001404329],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950842,0.0002753359,0.00002153885,0.0001683,0.00002744942,0.004144671,0.00003904224,0.0000172971,0.0002221803],"genre_scores_gemma":[0.9992291,0.0001328396,0.000239927,0.00004319012,0.00001491352,0.0001259613,0.000143808,0.00002343824,0.00004680844],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1486368,"threshold_uncertainty_score":0.7179578,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01584393636388485,"score_gpt":0.2899198745936451,"score_spread":0.2740759382297602,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}