{"id":"W2086786506","doi":"10.1530/endoabs.32.p845","title":"Pasireotide LAR and octreotide LAR maintain inhibition of GH and IGF1 in patients with acromegaly: 12-month extension phase of a randomized, double-blind, multicenter, phase III study","year":2013,"lang":"en","type":"article","venue":"Endocrine Abstracts","topic":"Pituitary Gland Disorders and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; Université de Montréal; Hôpital Notre-Dame","funders":"Novartis Pharmaceuticals Corporation","keywords":"Acromegaly; Pasireotide; Octreotide; Medicine; Double blind; Internal medicine; Phase (matter); Endocrinology; Somatostatin; Gastroenterology; Growth hormone; Chemistry; Pathology; Placebo","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00381506,0.00255202,0.004898565,0.0006916499,0.0007196259,0.001494639,0.001482218,0.002538798,0.005308065],"category_scores_gemma":[0.002087688,0.001159796,0.002796933,0.0006416762,0.002270844,0.002533664,0.0004724708,0.004800451,0.001584781],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001004781,"about_ca_system_score_gemma":0.00198714,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001466417,"about_ca_topic_score_gemma":0.002743874,"domain_scores_codex":[0.9988021,0.0005979624,0.00008431587,0.0001568832,0.00008859787,0.0002702548],"domain_scores_gemma":[0.9980842,0.0004910619,0.0003075204,0.0001891269,0.0001361413,0.00079196],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.967447,0.01249258,0.0005590959,0.0002491736,0.0004994412,0.00003363966,0.00006630908,0.0003526497,0.004099707,0.00006798832,0.0005095571,0.0136228],"study_design_scores_gemma":[0.9071496,0.09058886,0.001222105,0.00001178539,0.0001774558,0.00002293003,0.00002198922,0.0002098159,0.0003230005,0.00005389521,0.0002047325,0.00001383807],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9882728,0.002943945,0.0009106709,0.0007026172,0.0004188405,0.003856961,0.00110032,0.0001988795,0.00159492],"genre_scores_gemma":[0.9828773,0.002518022,0.002879093,0.001288221,0.0006132686,0.00523347,0.001658928,0.00006892203,0.002862713],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005308065,"threshold_uncertainty_score":0.02017617,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01584393636388485,"score_gpt":0.2899198745936451,"score_spread":0.2740759382297602,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}