{"id":"W2086793697","doi":"10.1007/s00439-004-1107-9","title":"Variants of CYP46A1 may interact with age and APOE to influence CSF A�42 levels in Alzheimer?s disease","year":2004,"lang":"en","type":"article","venue":"Human Genetics","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":62,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation; Hospital for Sick Children","funders":"Knut och Alice Wallenbergs Stiftelse; Fredrik och Ingrid Thurings Stiftelse; Petrus och Augusta Hedlunds Stiftelse; Pfizer","keywords":"Biology; Apolipoprotein E; Alzheimer's disease; Genotype; Alzheimer's Disease Neuroimaging Initiative; Genetics; Disease; Allele; SNP; Genetic association; Internal medicine; Single-nucleotide polymorphism; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006799577,0.0001727889,0.0002488653,0.0001636712,0.00005258597,0.00002387496,0.00009935058,0.00003709657,0.00005204207],"category_scores_gemma":[0.00002941593,0.000139777,0.00003418526,0.0001791928,0.0001509958,0.00006399939,0.00009644394,0.0001105502,0.00002858857],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000476512,"about_ca_system_score_gemma":0.000213007,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001139677,"about_ca_topic_score_gemma":0.0001011859,"domain_scores_codex":[0.9987771,0.00003024934,0.0002267802,0.0002970381,0.0003297266,0.000339092],"domain_scores_gemma":[0.9988729,0.00002166069,0.0000493503,0.0003599182,0.00009322631,0.000602974],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002079957,0.002814687,0.9673233,0.0002952883,0.004347579,0.008797804,0.002259169,0.001069891,0.004592726,0.0008218119,0.0001075717,0.005490223],"study_design_scores_gemma":[0.003082853,0.0007813442,0.9926564,0.0003653748,0.000384134,0.00001468465,0.00004609729,0.00001012453,0.001912108,0.000567626,0.00003929169,0.0001400163],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995571,0.003205545,0.00002790064,0.0001611533,0.00001046121,0.0005999964,0.00005967844,0.00001559458,0.0003486848],"genre_scores_gemma":[0.9983433,0.00007072384,0.001261435,0.0001906662,0.00002664271,0.00003144546,0.00002625177,0.00002750557,0.00002205959],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02533305,"threshold_uncertainty_score":0.5699939,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05459078069407675,"score_gpt":0.3536217605209401,"score_spread":0.2990309798268633,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}