{"id":"W2086806574","doi":"10.1038/35090602","title":"Catalysis by hen egg-white lysozyme proceeds via a covalent intermediate","year":2001,"lang":"en","type":"article","venue":"Nature","topic":"Enzyme Structure and Function","field":"Materials Science","cited_by":634,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Directorate for Biological Sciences; Natural Sciences and Engineering Research Council of Canada; Wellcome Trust","keywords":"Chemistry; Lysozyme; Glycosidic bond; Covalent bond; Catalysis; Electrospray ionization; Glycoside hydrolase; Stereochemistry; Catalytic cycle; Enzyme; Mass spectrometry; Organic chemistry; Biochemistry; Chromatography","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000169806,0.0001752597,0.0001931466,0.0000809856,0.00008733948,0.0000722528,0.0002678475,0.0006697273,0.001161305],"category_scores_gemma":[0.00004958712,0.0001365526,0.00007741804,0.0003331395,0.00006105197,0.0002245509,0.0000631032,0.0007689813,0.0002916981],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006216329,"about_ca_system_score_gemma":0.00002331715,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002221134,"about_ca_topic_score_gemma":0.00003546751,"domain_scores_codex":[0.9987884,0.00002718395,0.0001896601,0.0003577926,0.0003385143,0.0002984783],"domain_scores_gemma":[0.9994152,0.00001589302,0.00009853727,0.0002684508,0.0001038097,0.00009809991],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001786426,0.00008299276,0.008290324,0.00006164142,0.00004095682,0.00003369375,0.001180862,0.00001812858,0.8393957,0.0001309687,0.1446624,0.005923661],"study_design_scores_gemma":[0.001416924,0.0003249799,0.01298922,0.00007761085,0.0002354856,0.0002459488,0.0004146296,0.0002793751,0.5012791,0.0020148,0.4797834,0.0009384499],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884228,0.001783729,0.001496417,0.00125665,0.001793227,0.0002205692,0.00003588447,0.0002305132,0.004760221],"genre_scores_gemma":[0.9942749,0.00005287955,0.0004747514,0.001325732,0.0004407052,0.00001905033,0.0001044355,0.00002008805,0.003287485],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3381166,"threshold_uncertainty_score":0.9997517,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003936062534960601,"score_gpt":0.2271919685247363,"score_spread":0.2232559059897757,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}