{"id":"W2086812798","doi":"10.1016/j.devcel.2011.09.003","title":"Structural Basis of Wnt Signaling Inhibition by Dickkopf Binding to LRP5/6","year":2011,"lang":"en","type":"article","venue":"Developmental Cell","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":197,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Canadian Institutes of Health Research; National Institute on Aging; National Institutes of Health; U.S. Department of Energy","keywords":"Biology; Wnt signaling pathway; LRP5; Frizzled; Cell biology; Beta-catenin; Signal transduction; Computational biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001560122,0.0003461521,0.0002829789,0.0001335257,0.0003554062,0.0003127294,0.0005907391,0.0003837199,0.003634921],"category_scores_gemma":[0.0001727869,0.0002538961,0.0003461505,0.00006967116,0.0002929589,0.0002057189,0.0002602917,0.0006572974,0.001055439],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005727081,"about_ca_system_score_gemma":0.0002865157,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001445699,"about_ca_topic_score_gemma":0.001387345,"domain_scores_codex":[0.9998682,0.00002080269,0.00001147609,0.0000256998,0.00003687588,0.0000370969],"domain_scores_gemma":[0.9998834,0.00001652028,0.00004075001,0.00001137834,0.00001049348,0.00003742396],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002857945,0.00003615195,0.0001747938,0.00004630674,0.00001369484,0.0002352927,0.00001278933,0.0008357481,0.9953092,0.001733269,0.0001256596,0.001191409],"study_design_scores_gemma":[0.00004891739,0.0001179965,0.001995204,0.000006658436,0.00001592799,0.0002748214,0.0000184611,0.004280978,0.9910684,0.0002168347,0.001945749,0.0000101016],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9875354,0.001155551,0.005796771,0.0003752302,0.00008013031,0.00003233691,0.000252251,0.0001999613,0.004572385],"genre_scores_gemma":[0.9976529,0.0001830684,0.000894985,0.00006645788,0.000007700251,0.000007854401,0.0001241478,0.00001151026,0.001051341],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003634921,"threshold_uncertainty_score":0.01216006,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01679492524881164,"score_gpt":0.2090717028845296,"score_spread":0.192276777635718,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}