{"id":"W2086813209","doi":"10.1124/jpet.102.036053","title":"Amelioration of Chronic and Spontaneous Intestinal Inflammation with an Antisense Oligonucleotide (ISIS 9125) to Intracellular Adhesion Molecule-1 in the HLA-B27/β2 Microglobulin Transgenic Rat Model","year":2002,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Inflammation; Cell adhesion molecule; Transgene; Intercellular Adhesion Molecule-1; Tumor necrosis factor alpha; Systemic administration; Antisense therapy; Medicine; Genetically modified mouse; Beta-2 microglobulin; Immunology; Sense (electronics); Cancer research; Oligonucleotide; In vivo; Chemistry; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003012231,0.0009979773,0.0007337292,0.0007470279,0.0002977251,0.0003181193,0.000440313,0.000643497,0.001385828],"category_scores_gemma":[0.0001803643,0.0003037549,0.0005530255,0.0002545371,0.0006750523,0.0003873059,0.0001933578,0.001630024,0.0003189529],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003251921,"about_ca_system_score_gemma":0.0005119677,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006784396,"about_ca_topic_score_gemma":0.001382188,"domain_scores_codex":[0.9997469,0.00003335969,0.00001993682,0.00004040259,0.00005928649,0.0001002708],"domain_scores_gemma":[0.9996432,0.00003080408,0.0001218121,0.00004412742,0.0000203258,0.0001397226],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002326014,0.0009245711,0.0002804548,0.00006175421,0.00001584957,0.0002693686,0.00003043511,0.0001604862,0.9934453,0.0002016441,0.00007851411,0.002205607],"study_design_scores_gemma":[0.000642577,0.01363814,0.00455223,0.00001695696,0.00008872076,0.0006832204,0.00007308724,0.001322704,0.977775,0.0001210142,0.001069746,0.00001664607],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976072,0.0003985556,0.001059847,0.0001069136,0.0000442998,0.00003437067,0.0001128006,0.0001206637,0.0005152595],"genre_scores_gemma":[0.9948201,0.0005920428,0.001187864,0.00004605322,0.00003334181,0.00008244886,0.0002450787,0.00001792062,0.002975067],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001385828,"threshold_uncertainty_score":0.004636109,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.019613246694818,"score_gpt":0.2756996394863113,"score_spread":0.2560863927914933,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}