{"id":"W2086840280","doi":"10.1056/nejmra0802968","title":"Inherited Susceptibility to Common Cancers","year":2008,"lang":"en","type":"review","venue":"New England Journal of Medicine","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":569,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Medicine; Somatic cell; Germline; Germline mutation; Mutation; Gene; Prostate cancer; Genetics; Cancer; Cancer research; Oncology; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004522968,0.0002767109,0.001148349,0.0001749613,0.00004360931,0.000006020639,0.0003837843,0.0002291374,0.00009715617],"category_scores_gemma":[0.0003880467,0.0001901421,0.0002284173,0.0002631081,0.0001158288,0.000002401286,0.00006044134,0.0003956779,0.000005712817],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003150368,"about_ca_system_score_gemma":0.001918222,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001586013,"about_ca_topic_score_gemma":0.0003927947,"domain_scores_codex":[0.9982216,0.0002005246,0.0008313775,0.0002444532,0.0003090386,0.0001929802],"domain_scores_gemma":[0.9984605,0.00006341637,0.0005556685,0.0003916945,0.0002178546,0.0003108931],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007038577,0.00001063363,0.00002694899,0.0003454751,0.0001762194,0.00003504417,0.0001249038,0.00003217537,0.0001243145,0.00000109494,0.1087419,0.8903109],"study_design_scores_gemma":[0.00365135,0.0009964172,0.00001811808,0.002671257,0.000248212,0.001560498,0.00002133014,3.421436e-7,0.00003536017,0.0000139399,0.9906122,0.0001709836],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0007928401,0.9965011,0.0002668067,0.0005098799,0.001225566,0.0002394335,0.00001535183,0.000003634903,0.0004453366],"genre_scores_gemma":[0.0004394785,0.9896052,0.0005909617,0.0003796148,0.008404514,0.000005337418,0.00006834014,0.00003868763,0.0004678484],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8901399,"threshold_uncertainty_score":0.775377,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04301105648781125,"score_gpt":0.3634293314444438,"score_spread":0.3204182749566326,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}