{"id":"W2086869271","doi":"10.1523/jneurosci.5986-10.2011","title":"CCL2 Released from Neuronal Synaptic Vesicles in the Spinal Cord Is a Major Mediator of Local Inflammation and Pain after Peripheral Nerve Injury","year":2011,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":203,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Canadian Institutes of Health Research; Pfizer","keywords":"Proinflammatory cytokine; TRPV1; Neuropathic pain; Medicine; Nociception; Pharmacology; Spinal cord; Endocrinology; Peripheral nerve injury; Chemistry; Internal medicine; Sciatic nerve; Inflammation; Receptor; Transient receptor potential channel","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005862727,0.00009330181,0.0001925159,0.00009706528,0.00003176677,0.00001497358,0.0001226814,0.00003399045,0.0000205694],"category_scores_gemma":[0.0001985486,0.0000575987,0.0000581396,0.0001543398,0.0001671587,0.0001770354,0.00002279706,0.0001772959,7.176689e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002282029,"about_ca_system_score_gemma":0.00008373519,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004751308,"about_ca_topic_score_gemma":0.000006101457,"domain_scores_codex":[0.9987959,0.0001920279,0.0003477594,0.0001334581,0.0003974355,0.0001334771],"domain_scores_gemma":[0.9994378,0.00005994561,0.0002410012,0.0001135874,0.00005435645,0.00009330056],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.009614415,0.0007967721,0.1453314,0.00009539512,0.000036267,0.002321844,0.002962488,0.000001843573,0.7903553,0.0001807349,0.00008613808,0.04821733],"study_design_scores_gemma":[0.001052357,0.00509276,0.9746125,0.0001599537,0.00006001563,0.0001443902,0.0002841341,0.001236994,0.01673232,0.0005265659,0.00003941213,0.00005853984],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978994,0.0001338758,0.001207366,0.0005166405,0.0001211914,0.00010666,0.000005171933,0.000002474571,0.000007197747],"genre_scores_gemma":[0.9982012,0.00003255401,0.0006671701,0.001025986,0.00005976676,0.000003681577,2.162367e-7,0.00000587282,0.000003582337],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8292811,"threshold_uncertainty_score":0.2348807,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02398754910567215,"score_gpt":0.2656294133153608,"score_spread":0.2416418642096887,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}