{"id":"W2086874962","doi":"10.1016/j.ics.2005.02.024","title":"Single domain antibodies as blood–brain barrier delivery vectors","year":2005,"lang":"en","type":"article","venue":"International Congress Series","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute for Biological Sciences; National Research Council Canada","funders":"","keywords":"Transcytosis; Blood–brain barrier; Horseradish peroxidase; In vitro; In vivo; Antibody; Chemistry; Receptor; Transferrin receptor; Transferrin; Conjugate; Cell biology; Biochemistry; Biophysics; Biology; Endocytosis; Central nervous system; Immunology; Endocrinology; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001575767,0.0002204024,0.0002721609,0.0002067398,0.0001533456,0.000106782,0.0002617014,0.00009420874,0.003686676],"category_scores_gemma":[0.0002523721,0.0001843808,0.0001645291,0.0001055296,0.0003747624,0.0004201162,0.0001717635,0.0002428889,0.0004583519],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000750313,"about_ca_system_score_gemma":0.0001143866,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001547078,"about_ca_topic_score_gemma":0.0001369424,"domain_scores_codex":[0.9982236,0.00004976401,0.0003223666,0.0003211031,0.0007364109,0.0003467575],"domain_scores_gemma":[0.9989691,0.0001698451,0.00007703157,0.0001956583,0.0003821042,0.0002062591],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.007029694,0.001613286,0.2280394,0.0002669109,0.002889039,0.002518136,0.002793513,0.00004655518,0.5247837,0.06954833,0.1366435,0.02382802],"study_design_scores_gemma":[0.001059013,0.0004422101,0.009103905,0.0001410687,0.00003803987,0.000784746,0.0003213388,0.00005283474,0.1147442,0.001047778,0.8720101,0.0002548],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9236312,0.000977308,0.000005495317,0.0274877,0.0008743945,0.0001699353,0.00009876909,0.00008631526,0.04666886],"genre_scores_gemma":[0.8804529,0.0003000732,0.001506619,0.002181732,0.001115063,0.00002111537,0.0001346549,0.00002994656,0.1142579],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7353666,"threshold_uncertainty_score":0.9972241,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01899256358897874,"score_gpt":0.3057897856585816,"score_spread":0.2867972220696029,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}