{"id":"W2086874962","doi":"10.1016/j.ics.2005.02.024","title":"Single domain antibodies as blood–brain barrier delivery vectors","year":2005,"lang":"en","type":"article","venue":"International Congress Series","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute for Biological Sciences; National Research Council Canada","funders":"","keywords":"Transcytosis; Blood–brain barrier; Horseradish peroxidase; In vitro; In vivo; Antibody; Chemistry; Receptor; Transferrin receptor; Transferrin; Conjugate; Cell biology; Biochemistry; Biophysics; Biology; Endocytosis; Central nervous system; Immunology; Endocrinology; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006140352,0.0005783094,0.0003995548,0.0007387175,0.0002459975,0.0008466976,0.0005423847,0.0005186551,0.003023662],"category_scores_gemma":[0.0001722152,0.0002952745,0.0003469455,0.0003351903,0.0002911907,0.0006607522,0.0002854597,0.0007520746,0.001279956],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005236387,"about_ca_system_score_gemma":0.0003476738,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004350181,"about_ca_topic_score_gemma":0.0008652606,"domain_scores_codex":[0.9998304,0.00003728828,0.00001185839,0.00002838249,0.00005554712,0.0000365832],"domain_scores_gemma":[0.9999242,0.00002129639,0.00001230451,0.000007100365,0.00001909488,0.00001611791],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002398548,0.0001061976,0.00009251802,0.0002536867,0.00002885374,0.00008145711,0.00005784597,0.000442286,0.9301099,0.005746457,0.002716522,0.06012448],"study_design_scores_gemma":[0.00003337256,0.0004147942,0.0002687983,0.00001637474,0.00004924653,0.0002543929,0.00001201448,0.001083655,0.9617905,0.0004160715,0.03565143,0.000009267013],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5660019,0.1460745,0.2410523,0.002143068,0.002927331,0.0006586953,0.0008489574,0.001768921,0.03852426],"genre_scores_gemma":[0.6935095,0.09090354,0.1229662,0.0004328844,0.000386159,0.0005939257,0.001418212,0.0002671789,0.08952226],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003023662,"threshold_uncertainty_score":0.01011515,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01899256358897874,"score_gpt":0.3057897856585816,"score_spread":0.2867972220696029,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}