{"id":"W2086884652","doi":"10.1002/ajmg.10212","title":"Serious genetic disorders: Can or should they be defined?*","year":2002,"lang":"en","type":"article","venue":"American Journal of Medical Genetics","topic":"Palliative Care and End-of-Life Issues","field":"Medicine","cited_by":105,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"National Human Genome Research Institute; National Institutes of Health","keywords":"Certification; Medical genetics; Genetic counseling; Genetic testing; Family medicine; Medicine; Psychology; Law; Genetics; Political science; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01873947,0.0007769408,0.001336128,0.00487254,0.002168877,0.003990945,0.002583778,0.004218323,0.005314745],"category_scores_gemma":[0.07652766,0.0003889856,0.0007547411,0.005209437,0.008477949,0.01179987,0.003087415,0.006319315,0.001790804],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001807139,"about_ca_system_score_gemma":0.006088091,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01036646,"about_ca_topic_score_gemma":0.01703621,"domain_scores_codex":[0.9888335,0.005081559,0.003282203,0.0009357485,0.00123948,0.0006274283],"domain_scores_gemma":[0.9361696,0.03155707,0.009320623,0.002593653,0.01389657,0.0064624],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0006287067,0.0003809866,0.1637545,0.004646903,0.0001257713,0.001401995,0.008545938,0.000299567,0.0002737828,0.05778665,0.3724094,0.3897458],"study_design_scores_gemma":[0.0004214782,0.0005933139,0.1330599,0.03845402,0.0002958986,0.01192348,0.07279788,0.001808591,0.0004012604,0.2187051,0.5210931,0.0004459081],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.03770543,0.1598176,0.009041001,0.7577013,0.01692932,0.0003627549,0.00166056,0.000115915,0.01666609],"genre_scores_gemma":[0.4251988,0.2066881,0.04003153,0.2816736,0.03119046,0.00169592,0.006409263,0.0002478414,0.006864591],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.01873947,"threshold_uncertainty_score":0.099105,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1258153809246122,"score_gpt":0.4025846223658914,"score_spread":0.2767692414412792,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}