{"id":"W2086887789","doi":"10.1111/j.1742-7843.2006.00010.x","title":"Vanilloid (Subtype 1) Receptor‐Modulatory Drugs Inhibit [<sup>3</sup>H]Batrachotoxinin‐A 20‐α‐benzoate Binding to Na<sup>+</sup>Channels","year":2006,"lang":"en","type":"article","venue":"Basic & Clinical Pharmacology & Toxicology","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Capsazepine; Chemistry; Sodium channel; Batrachotoxin; Veratridine; Capsaicin; Pharmacology; Depolarization; Sodium; Radioligand; Biophysics; Receptor; Allosteric regulation; TRPV1; Stereochemistry; Biochemistry; Transient receptor potential channel; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts","research_integrity","insufficient_payload"],"consensus_categories":["metaepi_narrow","sts","research_integrity","insufficient_payload"],"category_scores_codex":[0.004145584,0.001285721,0.001981611,0.001326459,0.001469469,0.0001934547,0.003128954,0.001402242,0.004328456],"category_scores_gemma":[0.002371367,0.001304069,0.000816306,0.002818602,0.003435909,0.0008494327,0.001758637,0.00443797,0.009363283],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004283331,"about_ca_system_score_gemma":0.001060223,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002961389,"about_ca_topic_score_gemma":0.000006041188,"domain_scores_codex":[0.9815101,0.005699789,0.002977207,0.004514354,0.001309869,0.003988679],"domain_scores_gemma":[0.9887617,0.00724719,0.0007660195,0.0011382,0.0003350155,0.001751823],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001244927,0.00222507,0.002684142,0.00005109249,0.00005286132,0.001002135,0.0002724696,0.009658973,0.8530907,0.0002442427,0.1261804,0.003292993],"study_design_scores_gemma":[0.007019867,0.003554076,0.0004464052,0.00003594728,0.0002390703,0.0002778356,0.0001231791,0.0130898,0.7961116,0.0002980727,0.1772799,0.001524261],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9749498,0.0001105146,0.00003841192,0.01126871,0.008287751,0.001917874,0.00018626,0.0009845251,0.00225612],"genre_scores_gemma":[0.9246413,0.000413709,0.0001443801,0.05873962,0.003693766,0.0006121962,0.00001749754,0.0002945406,0.01144297],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05697907,"threshold_uncertainty_score":0.9999894,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06939837007121354,"score_gpt":0.3882575302684993,"score_spread":0.3188591601972858,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}