{"id":"W2086891449","doi":"10.1074/jbc.m412687200","title":"Iron Inactivates the RNA Polymerase NS5B and Suppresses Subgenomic Replication of Hepatitis C Virus","year":2005,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Hepatitis C virus research","field":"Medicine","cited_by":111,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Sherbrooke; Jewish General Hospital","funders":"Canadian Institutes of Health Research","keywords":"NS5B; Virology; Replicon; Hepatitis C virus; Subgenomic mRNA; Polymerase; RNA; Viral replication; Biology; RNA-dependent RNA polymerase; RNA polymerase; NS2-3 protease; Virus; Molecular biology; Chemistry; Enzyme; Hepacivirus; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003826306,0.00008939947,0.0002678651,0.00002517984,0.00004391294,0.00001213909,0.0001477318,0.0001254832,0.0003367619],"category_scores_gemma":[0.0009112117,0.00005127623,0.00008145256,0.00008154511,0.0002319464,0.00005689286,0.0000595228,0.0003333052,0.000003003665],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007404909,"about_ca_system_score_gemma":0.00007248895,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001038104,"about_ca_topic_score_gemma":0.000005250638,"domain_scores_codex":[0.9990413,0.00004953768,0.0004100299,0.0001448809,0.0002053907,0.0001488584],"domain_scores_gemma":[0.9989864,0.0002302706,0.000271121,0.0002561234,0.0001270457,0.000129043],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002120169,0.0001072579,0.06285162,0.00004396101,0.00002944357,0.00001550178,0.00003690825,0.000001098337,0.906719,0.000003744987,0.000388858,0.02959055],"study_design_scores_gemma":[0.0004130672,0.0002226117,0.07652345,0.00004596181,0.00002078132,0.0001674481,0.00002699423,0.00002978337,0.9185697,0.00003539865,0.00389444,0.00005034286],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941921,0.002299568,0.00001241874,0.00238556,0.00001311115,0.00007973357,0.00001723421,0.000006130984,0.0009941184],"genre_scores_gemma":[0.9931934,0.005988953,0.0002637158,0.0001425873,0.0003105432,0.000003184506,0.000006609466,0.000006667718,0.00008429657],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0295402,"threshold_uncertainty_score":0.3687307,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0314666232505859,"score_gpt":0.3118586903968911,"score_spread":0.2803920671463052,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}