{"id":"W2086892854","doi":"10.1007/s00401-012-1017-1","title":"The MAPT H1 haplotype is associated with tangle-predominant dementia","year":2012,"lang":"en","type":"article","venue":"Acta Neuropathologica","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":82,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"National Institute of Neurological Disorders and Stroke; National Institute on Aging","keywords":"Tau protein; Haplotype; Neurofibrillary tangle; Alzheimer's disease; Dementia; Tangle; Pathology; Cognitive decline; Biology; Psychology; Allele; Genetics; Disease; Medicine; Gene; Senile plaques","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001827618,0.0008508149,0.0004872369,0.001119016,0.0009013368,0.000457884,0.0005312101,0.001123267,0.01115253],"category_scores_gemma":[0.00141232,0.0002997052,0.0003705552,0.0009041438,0.0003808286,0.0003987831,0.0002977035,0.0006060558,0.001194898],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001543372,"about_ca_system_score_gemma":0.0001556208,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001617218,"about_ca_topic_score_gemma":0.001013797,"domain_scores_codex":[0.9997621,0.00006004727,0.00002862422,0.00006642261,0.00003832825,0.00004449352],"domain_scores_gemma":[0.9989403,0.0003621907,0.0003528402,0.00006056856,0.00007731536,0.000206849],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01175621,0.001069135,0.7416328,0.0002648998,0.0009798743,0.06738099,0.00130098,0.0008057094,0.1490416,0.001178268,0.003664291,0.02092521],"study_design_scores_gemma":[0.0002846725,0.001120649,0.9458605,0.00006936672,0.0003865716,0.04134957,0.0004534556,0.001289684,0.005744237,0.001334449,0.002045206,0.00006163558],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969631,0.000248918,0.0003596453,0.0001657386,0.00005045962,0.0000104478,0.0003454183,0.00002719747,0.001828889],"genre_scores_gemma":[0.998763,0.00007246852,0.0001490095,0.00004781498,0.00007911208,0.00000599496,0.0001703729,0.00001245324,0.0006999704],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01115253,"threshold_uncertainty_score":0.03730893,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03403705640348369,"score_gpt":0.2842991972138615,"score_spread":0.2502621408103778,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}