{"id":"W2086897927","doi":"10.1128/mcb.01554-13","title":"Unraveling the Complexities of DNA-Dependent Protein Kinase Autophosphorylation","year":2014,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; McMaster University","funders":"National Institute of Allergy and Infectious Diseases; U.S. Public Health Service","keywords":"Autophosphorylation; Biology; DNA damage; DNA repair; Phosphorylation; DNA; Replication protein A; Cell biology; Non-homologous end joining; DNA-PKcs; DNA replication; Protein subunit; Protein kinase A; Molecular biology; Genetics; DNA-binding protein; Transcription factor; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000705213,0.0005283663,0.0006729868,0.0003755632,0.0006030817,0.002328629,0.0007672968,0.0008501618,0.00115529],"category_scores_gemma":[0.0007103921,0.0005377469,0.0004058625,0.000309353,0.001551221,0.004564595,0.001033109,0.004665999,0.0006023906],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007085689,"about_ca_system_score_gemma":0.0008976451,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005327541,"about_ca_topic_score_gemma":0.001097877,"domain_scores_codex":[0.9997436,0.00003432364,0.00002203441,0.00007310137,0.00006623497,0.00006058282],"domain_scores_gemma":[0.9995626,0.0001586416,0.00007607991,0.00006509476,0.00005571186,0.00008193245],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004898057,0.0002119282,0.007331337,0.00182435,0.000105334,0.0030943,0.001250313,0.009501915,0.712658,0.1028708,0.005178535,0.1554834],"study_design_scores_gemma":[0.0001478843,0.0005414052,0.02372391,0.0007395901,0.0002554968,0.006159022,0.00337848,0.1029141,0.3431692,0.2220604,0.2966588,0.0002517383],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7291313,0.1517062,0.07080932,0.02403978,0.001192925,0.00006421975,0.0003225354,0.001070688,0.02166295],"genre_scores_gemma":[0.902916,0.0697071,0.0200191,0.001711892,0.0006387376,0.00005120498,0.0002513302,0.0001245122,0.004580103],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002328629,"threshold_uncertainty_score":0.00514102,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007232848466287631,"score_gpt":0.2114978213285927,"score_spread":0.2042649728623051,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}