{"id":"W2086898460","doi":"10.1016/j.virol.2011.09.025","title":"Adenovirus E1A interacts directly with, and regulates the level of expression of, the immunoproteasome component MECL1","year":2011,"lang":"en","type":"article","venue":"Virology","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"Medical Research Council; University of Birmingham; Cancer Research UK","keywords":"Proteasome; Protein subunit; Biology; Cell biology; Interferon; STAT1; Phosphorylation; Transfection; Molecular biology; Biochemistry; Virology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003209836,0.0003204137,0.0002426815,0.0003457763,0.0003325374,0.001100158,0.0002354158,0.000305788,0.00150992],"category_scores_gemma":[0.0003540811,0.0002980735,0.0003614176,0.0001688397,0.0003383436,0.0004748472,0.0003942087,0.0006404152,0.00080149],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001175482,"about_ca_system_score_gemma":0.000255772,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008887042,"about_ca_topic_score_gemma":0.001156007,"domain_scores_codex":[0.999603,0.00005827763,0.00003214283,0.00009572431,0.0000911137,0.0001197033],"domain_scores_gemma":[0.9997067,0.0000726015,0.00007025541,0.00004577478,0.0000360238,0.00006854958],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001316198,0.00001420491,0.0004181744,0.0000181041,0.000004822378,0.00002516086,0.00001050144,0.00003278629,0.9986377,0.0001469095,0.00004206966,0.0005178798],"study_design_scores_gemma":[0.00001177817,0.00004835095,0.009042579,0.000005449685,0.00001068267,0.0001424863,0.00005021187,0.0009845216,0.9875004,0.00008142888,0.002116948,0.000005149218],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905834,0.003675773,0.002983291,0.0002225032,0.00006598789,0.000008053127,0.0003174083,0.00008941956,0.002054192],"genre_scores_gemma":[0.9945647,0.0006412021,0.001183039,0.00006218734,0.00001298728,0.000009152798,0.0005092495,0.00003154923,0.002985834],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00150992,"threshold_uncertainty_score":0.008528709,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04152478057205398,"score_gpt":0.2356768325276263,"score_spread":0.1941520519555723,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}