{"id":"W2086909723","doi":"10.1073/pnas.0903676106","title":"Calcium signaling cascade links dopamine D1–D2 receptor heteromer to striatal BDNF production and neuronal growth","year":2009,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Neurotransmitter Receptor Influence on Behavior","field":"Neuroscience","cited_by":268,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"National Institute on Drug Abuse","keywords":"Nucleus accumbens; Dopaminergic; Brain-derived neurotrophic factor; Dopamine; Dopamine receptor D2; Biology; Neuroscience; Glial cell line-derived neurotrophic factor; Cell biology; Neurotrophic factors; Chemistry; Internal medicine; Endocrinology; Receptor; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008062178,0.0001863625,0.0001269604,0.0001302942,0.0001908856,0.0002569714,0.000129229,0.0002302157,0.001453458],"category_scores_gemma":[0.00008522833,0.0001285698,0.000122648,0.00006542919,0.0001752673,0.00018058,0.0002147063,0.0003649011,0.0002428656],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000596637,"about_ca_system_score_gemma":0.0002289542,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001034424,"about_ca_topic_score_gemma":0.002930781,"domain_scores_codex":[0.9999222,0.000008887296,0.000003972409,0.00002615402,0.00001889071,0.00002006385],"domain_scores_gemma":[0.9999608,0.000005719693,0.00001151482,0.000003331247,0.000004531222,0.00001401685],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004871356,0.000006769496,0.0001002053,0.000007797203,0.000001604205,0.00003524472,0.000005168432,0.00002488136,0.9992755,0.00009614859,0.00002130583,0.0003767092],"study_design_scores_gemma":[0.00006197586,0.0001446051,0.0221414,0.000009101582,0.00001614247,0.0004775781,0.0000515188,0.001854545,0.9727772,0.0002513268,0.002207625,0.000007014341],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947924,0.0008986376,0.001687772,0.0002131336,0.00001379633,0.00001241027,0.0001869893,0.00002493347,0.002169979],"genre_scores_gemma":[0.9965456,0.0005959368,0.001052944,0.00007169145,0.000007380452,0.00001839265,0.000173881,0.0000050135,0.001529199],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001453458,"threshold_uncertainty_score":0.004862309,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06431519037031729,"score_gpt":0.3210647140106751,"score_spread":0.2567495236403578,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}