{"id":"W2086912092","doi":"10.1097/fpc.0b013e32832c484b","title":"Induction of 1C aldoketoreductases and other drug dose-dependent genes upon acquisition of anthracycline resistance","year":2009,"lang":"en","type":"article","venue":"Pharmacogenetics and Genomics","topic":"Aldose Reductase and Taurine","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"NOSM University; Laurentian University; University of Ottawa; Sudbury Regional Hospital","funders":"Cancer Care Ontario","keywords":"Anthracycline; Doxorubicin; Biology; Drug resistance; Epirubicin; ABCC1; Cancer research; Gene; ATP-binding cassette transporter; Biochemistry; Microbiology; Genetics; Cancer; Chemotherapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001270203,0.0001432887,0.0001750183,0.00004992078,0.00004848652,0.00000917227,0.00007315569,0.00006532625,0.00001006276],"category_scores_gemma":[0.000005683958,0.0001426474,0.00004113128,0.00004921078,0.00009316331,0.000004689566,0.00004897103,0.00004422221,3.304314e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006895569,"about_ca_system_score_gemma":0.00003514679,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001446311,"about_ca_topic_score_gemma":0.00001217071,"domain_scores_codex":[0.9992009,0.00003341371,0.0002792522,0.0002578335,0.00009124098,0.0001373569],"domain_scores_gemma":[0.9995127,0.000006777355,0.0001719703,0.0001677512,0.0000713285,0.00006944578],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000231189,0.0001053871,0.0006104983,0.00004370171,0.00005795103,0.000001280991,0.00007613159,0.00008267379,0.9829075,0.00007352768,0.0001698338,0.01564028],"study_design_scores_gemma":[0.0007648467,0.0001445384,0.00221725,0.00001436859,0.00007534479,0.00001927304,0.00007475453,0.00005508796,0.9815053,0.0002951703,0.01468314,0.0001508981],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9692295,0.03003679,0.0001039043,0.0001618827,0.00008444783,0.0001488226,0.0001372612,0.000004156494,0.00009325814],"genre_scores_gemma":[0.979302,0.018961,0.001189035,0.0001474314,0.0002552475,0.000002758138,0.00005381521,0.0000159895,0.00007267672],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01548938,"threshold_uncertainty_score":0.5816991,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01183843552418324,"score_gpt":0.2784200341925055,"score_spread":0.2665815986683223,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}