{"id":"W2086921761","doi":"10.1158/1535-7163.targ-11-a229","title":"Abstract A229: BRAF inhibitors upregulate EGFR ligands: A molecular link to RAF inhibitor-induced cutaneous squamous cell carcinomas.","year":2011,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Workplace Health, Safety and Compensation Commission","funders":"","keywords":"Vemurafenib; Cancer research; HRAS; Melanoma; Cancer; Downregulation and upregulation; Neuroblastoma RAS viral oncogene homolog; EGFR inhibitors; MAPK/ERK pathway; Skin cancer; Kinase; Cell growth; Medicine; Biology; KRAS; Epidermal growth factor receptor; Internal medicine; Colorectal cancer; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001677759,0.0003751297,0.0002411806,0.0004101404,0.0001882072,0.0004665565,0.0004404784,0.0005191129,0.02021121],"category_scores_gemma":[0.0001604121,0.000176102,0.0002272422,0.0001658941,0.0001435088,0.0003485082,0.0001681452,0.0005188217,0.003118386],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003494449,"about_ca_system_score_gemma":0.0002657748,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007507924,"about_ca_topic_score_gemma":0.0007251066,"domain_scores_codex":[0.9999008,0.00001488245,0.000009479964,0.00002347558,0.00003445104,0.00001683563],"domain_scores_gemma":[0.9999013,0.00001890809,0.00002101366,0.00001136256,0.00001806827,0.00002932728],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001601515,0.0003862121,0.001328247,0.0003615148,0.00003266439,0.001711155,0.00003237602,0.0001952844,0.9480156,0.001731936,0.007983708,0.03661989],"study_design_scores_gemma":[0.0002363973,0.002927992,0.02145191,0.00002620799,0.00006105953,0.005350924,0.00005506535,0.001357642,0.9205984,0.0007835652,0.04713218,0.00001863972],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.897329,0.0114446,0.008821025,0.002682778,0.002649731,0.0004203322,0.004171004,0.00150218,0.07097931],"genre_scores_gemma":[0.9164674,0.002548097,0.002302006,0.0004513032,0.0003160366,0.00009203034,0.001441393,0.0001083428,0.07627346],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02021121,"threshold_uncertainty_score":0.06761324,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02256382766487966,"score_gpt":0.2431232919268744,"score_spread":0.2205594642619947,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}