{"id":"W2086922697","doi":"10.1139/o09-060","title":"Wogonin induces G<sub>1</sub> phase arrest through inhibiting Cdk4 and cyclin D1 concomitant with an elevation in p21<sup>Cip1</sup> in human cervical carcinoma HeLa cells","year":2009,"lang":"en","type":"article","venue":"Biochemistry and Cell Biology","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Natural Science Foundation of China","keywords":"Wogonin; HeLa; Cyclin D1; Cyclin-dependent kinase; Cancer research; Gene silencing; Chemistry; Cell cycle; Cell cycle checkpoint; Cell biology; Biology; Molecular biology; Apoptosis; In vitro; Medicine; Scutellaria baicalensis; Biochemistry; Gene; Pathology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003617893,0.0002367047,0.0001565199,0.0003025113,0.0001176437,0.0001456801,0.0000744809,0.0001305585,0.0008034682],"category_scores_gemma":[0.00005820356,0.0001108292,0.0002055636,0.0001456531,0.0001509603,0.0001204982,0.0001164501,0.0002506265,0.0001914784],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003220666,"about_ca_system_score_gemma":0.0001489824,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009504071,"about_ca_topic_score_gemma":0.001392741,"domain_scores_codex":[0.9999681,0.000004669246,0.00000289259,0.000007618204,0.000006524291,0.00001022141],"domain_scores_gemma":[0.9999772,0.000004546247,0.000007340389,0.000002955361,0.000003053935,0.000004777949],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001141355,0.00001426855,0.0001234233,0.00003732149,0.000002717446,0.00003211927,0.000005607374,0.0000369698,0.9987599,0.00004057934,0.00002050728,0.0008123991],"study_design_scores_gemma":[0.00002039805,0.0002158485,0.005983873,0.000004052025,0.000008645714,0.00009620265,0.00001560123,0.0003338856,0.9914011,0.00005410708,0.001863604,0.000002673611],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935085,0.00264361,0.001392258,0.00008661236,0.00002540333,0.00004839138,0.0005185365,0.00006175896,0.00171508],"genre_scores_gemma":[0.9934924,0.00175178,0.001392098,0.00007295045,0.000008074365,0.00005857933,0.0007793545,0.00001812178,0.002426619],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009504071,"threshold_uncertainty_score":0.002687871,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01291341959396945,"score_gpt":0.2611955517880046,"score_spread":0.2482821321940352,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}