{"id":"W2086922697","doi":"10.1139/o09-060","title":"Wogonin induces G<sub>1</sub> phase arrest through inhibiting Cdk4 and cyclin D1 concomitant with an elevation in p21<sup>Cip1</sup> in human cervical carcinoma HeLa cells","year":2009,"lang":"en","type":"article","venue":"Biochemistry and Cell Biology","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Natural Science Foundation of China","keywords":"Wogonin; HeLa; Cyclin D1; Cyclin-dependent kinase; Cancer research; Gene silencing; Chemistry; Cell cycle; Cell cycle checkpoint; Cell biology; Biology; Molecular biology; Apoptosis; In vitro; Medicine; Scutellaria baicalensis; Biochemistry; Gene; Pathology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002071075,0.0002817862,0.0004319636,0.00008241316,0.00007624924,0.00001970183,0.00007407869,0.0005028018,0.000009457376],"category_scores_gemma":[0.00002948567,0.0002597054,0.00003038017,0.0002247034,0.0002310549,0.00006421488,0.00003900139,0.0005279346,0.000001441032],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009615357,"about_ca_system_score_gemma":0.0001192947,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008231018,"about_ca_topic_score_gemma":0.00004316887,"domain_scores_codex":[0.9983404,0.00008969697,0.0004356216,0.0006387726,0.00009483092,0.0004006564],"domain_scores_gemma":[0.9993759,0.00004983334,0.0001415115,0.0002317696,0.00004171154,0.0001592051],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005854666,0.0004330535,0.00338534,0.0001025772,0.000009849197,0.0001874304,0.0004911548,0.00001184452,0.9927731,0.00003673808,0.00001230655,0.00197112],"study_design_scores_gemma":[0.007357644,0.001772475,0.002162212,0.0001912795,0.00003774486,0.0000777264,0.0006747754,0.0002798104,0.9869778,0.0001174893,0.00006470041,0.0002863486],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972454,0.001321391,0.00002153591,0.0002290893,0.00003112284,0.0003142735,0.00002350002,0.00003223762,0.000781436],"genre_scores_gemma":[0.9988525,0.0001556699,0.0001578133,0.0003338201,0.0001494379,0.00001863897,0.0002985322,0.00001952553,0.00001406082],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006772177,"threshold_uncertainty_score":0.9999855,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01291341959396945,"score_gpt":0.2611955517880046,"score_spread":0.2482821321940352,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}