{"id":"W2086955443","doi":"10.1074/jbc.m112.352484","title":"Deconjugation of Nedd8 from Cul1 Is Directly Regulated by Skp1-F-box and Substrate, and the COP9 Signalosome Inhibits Deneddylated SCF by a Noncatalytic Mechanism","year":2012,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":120,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; National Cancer Institute; Canadian Institutes of Health Research; Howard Hughes Medical Institute","keywords":"Skp1; COP9 signalosome; Cell division control protein 4; NEDD8; Ubiquitin ligase; Cullin; Ubiquitin; Substrate (aquarium); Chemistry; F-box protein; SKP2; Biochemistry; Enzyme; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004628702,0.0001881803,0.0003304875,0.00001218366,0.00006746255,0.00002542193,0.0001591724,0.0003687753,0.00006618497],"category_scores_gemma":[0.0001378054,0.0001181693,0.00009721736,0.00007014711,0.0002860782,0.00001403218,0.00008643688,0.0002004418,9.572409e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001192881,"about_ca_system_score_gemma":0.00003261885,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001500858,"about_ca_topic_score_gemma":4.166719e-7,"domain_scores_codex":[0.9989127,0.00008060387,0.0004533553,0.0001982604,0.0001359513,0.0002191626],"domain_scores_gemma":[0.9990181,0.00008288128,0.0004614062,0.0001394213,0.0001249294,0.0001732863],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003631353,0.00007648124,0.002042705,0.00001960675,0.0001061902,0.000001011653,0.00007313512,1.459178e-7,0.9963077,0.000008998165,0.0006568144,0.0003441312],"study_design_scores_gemma":[0.001717897,0.0001763216,0.0004384397,0.00004397674,0.00005090647,0.00008680017,0.00008178277,0.00001670009,0.9959252,0.0006983479,0.0006124697,0.0001510995],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9852427,0.01402195,0.00009961704,0.0001733973,0.00002964363,0.0001105563,0.0001474051,0.000005057195,0.0001697172],"genre_scores_gemma":[0.9979238,0.001348586,0.0001433794,0.0002010439,0.0001450745,0.000004453992,0.0001376518,0.00001092814,0.00008507755],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01268115,"threshold_uncertainty_score":0.4818803,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0108947350877826,"score_gpt":0.2218396655537687,"score_spread":0.2109449304659861,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}