{"id":"W2086955443","doi":"10.1074/jbc.m112.352484","title":"Deconjugation of Nedd8 from Cul1 Is Directly Regulated by Skp1-F-box and Substrate, and the COP9 Signalosome Inhibits Deneddylated SCF by a Noncatalytic Mechanism","year":2012,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":120,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; National Cancer Institute; Canadian Institutes of Health Research; Howard Hughes Medical Institute","keywords":"Skp1; COP9 signalosome; Cell division control protein 4; NEDD8; Ubiquitin ligase; Cullin; Ubiquitin; Substrate (aquarium); Chemistry; F-box protein; SKP2; Biochemistry; Enzyme; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002203024,0.0003696083,0.0002624627,0.00008489568,0.00009773907,0.0003526073,0.0001837171,0.0001364548,0.0006326181],"category_scores_gemma":[0.0001639775,0.0001454502,0.000225097,0.00009362627,0.0001464885,0.0002471787,0.0001934534,0.0003545717,0.0003779161],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000405631,"about_ca_system_score_gemma":0.0002196564,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006742085,"about_ca_topic_score_gemma":0.0008802388,"domain_scores_codex":[0.9997975,0.00002955037,0.00002569142,0.00005304589,0.00005803338,0.00003609479],"domain_scores_gemma":[0.9998935,0.0000182651,0.00003334893,0.00001592307,0.0000213364,0.00001753908],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004852782,0.00001541081,0.0004395991,0.00003346065,0.000008367453,0.0000282335,0.00001242303,0.00008625112,0.9981518,0.0001187415,0.00002678073,0.001030399],"study_design_scores_gemma":[0.000001405805,0.00002279835,0.001177092,0.000001254635,0.00000193279,0.00004877853,0.000005781355,0.0005843468,0.9976944,0.000008209066,0.0004526123,0.00000139826],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942426,0.0008079862,0.004029953,0.00002669299,0.000008877225,0.00001204688,0.0001544397,0.00003449043,0.0006829269],"genre_scores_gemma":[0.9955231,0.000419142,0.001857291,0.00001410474,0.00000153553,0.00001056293,0.0004321497,0.00001903632,0.001723004],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006742085,"threshold_uncertainty_score":0.002943039,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0108947350877826,"score_gpt":0.2218396655537687,"score_spread":0.2109449304659861,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}