{"id":"W2086956731","doi":"10.1016/j.rbmo.2011.03.011","title":"Response: Cell fate in the early mouse embryo – sorting out the influence of developmental history on lineage choice","year":2011,"lang":"en","type":"letter","venue":"Reproductive BioMedicine Online","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"","keywords":"Epiblast; Blastocyst; Inner cell mass; Endoderm; Biology; Embryonic stem cell; Embryo; Yolk sac; Cell biology; Progenitor cell; Lineage (genetic); Embryogenesis; Andrology; Genetics; Stem cell; Gastrulation; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002424371,0.0004442826,0.0004534322,0.0003173737,0.00007829657,0.000008922409,0.001248331,0.0004873573,0.00002033982],"category_scores_gemma":[0.00157375,0.0002680055,0.0001344231,0.0002697109,0.0007685032,0.000007165017,0.0003350114,0.001587113,0.00003258992],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002330291,"about_ca_system_score_gemma":0.0005077446,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003597501,"about_ca_topic_score_gemma":0.00003380152,"domain_scores_codex":[0.9957764,0.0009098732,0.0007600848,0.001186881,0.0008199238,0.0005468064],"domain_scores_gemma":[0.9972568,0.0002381289,0.0005780459,0.001558223,0.0003176446,0.0000512173],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006102548,0.0002449509,0.0004791513,0.000146022,0.00007793,0.0001055543,0.001037651,0.0000108168,0.8137963,2.756028e-7,0.1832914,0.0001997345],"study_design_scores_gemma":[0.0007517903,0.0008577916,0.01629805,0.0001592091,0.00003863465,0.00002795612,0.0002190279,0.000002479802,0.1541438,0.000002577372,0.8271567,0.0003420363],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.932167,0.001813392,0.000006161569,0.06424978,0.0002638875,0.0008983514,0.0001490167,0.0000130095,0.0004394275],"genre_scores_gemma":[0.6105986,0.001562915,0.0009976985,0.2459394,0.01615185,0.0003429129,0.004158202,0.0004343859,0.119814],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6596525,"threshold_uncertainty_score":0.9999772,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03297954545100616,"score_gpt":0.2848951832134172,"score_spread":0.251915637762411,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}