{"id":"W2086968510","doi":"10.1021/bi035667n","title":"Molecular Mechanism of the Enterococcal Aminoglycoside 6‘-<i>N</i>-Acetyltransferase‘:  Role of GNAT-Conserved Residues in the Chemistry of Antibiotic Inactivation","year":2003,"lang":"en","type":"article","venue":"Biochemistry","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Active site; Residue (chemistry); Biochemistry; Stereochemistry; Chemistry; Acetyltransferase; Acetyltransferases; Enterococcus hirae; Enzyme; Site-directed mutagenesis; Mutant; Aminoglycoside; Protein superfamily; Biology; Antibiotics; Acetylation; Enterococcus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003437044,0.0001997311,0.0002446558,0.00002357065,0.00003296125,0.000007036936,0.000607437,0.0002997658,0.00001330308],"category_scores_gemma":[0.0003300422,0.0001448243,0.0002237337,0.0002706556,0.0003217355,0.000003489649,0.0001080266,0.0002156929,2.825333e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001753151,"about_ca_system_score_gemma":0.0001687456,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005800298,"about_ca_topic_score_gemma":0.000005064514,"domain_scores_codex":[0.9984512,0.0001500724,0.0004384062,0.0003406024,0.0003604969,0.0002591881],"domain_scores_gemma":[0.9988537,0.00003009883,0.0001819664,0.0007431172,0.0001430757,0.00004803732],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009536253,0.0002472892,0.001915798,0.0002851547,0.00004483768,0.000002391547,0.00004528744,0.000005134465,0.9969056,0.0003316378,0.00003735917,0.00008414804],"study_design_scores_gemma":[0.0005771396,0.00007059397,0.0005864149,0.000106806,0.00002290424,0.00002246614,0.000362688,0.000008445229,0.9976992,0.0002873014,0.000118326,0.0001377151],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966335,0.001075237,0.0001389908,0.0001022374,0.00001853273,0.0002582774,0.00003621691,0.000003471708,0.001733535],"genre_scores_gemma":[0.9995749,0.00007563255,0.000135586,0.00006550851,0.00001820165,0.00001510316,0.00004590307,0.00001911233,0.00005004114],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002941411,"threshold_uncertainty_score":0.5905765,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006619452523878033,"score_gpt":0.2251150008053462,"score_spread":0.2184955482814681,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}