{"id":"W2086971446","doi":"10.1016/j.mrfmmm.2006.04.005","title":"Formamidopyrimidine adducts are detected using the comet assay in human cells treated with reactive metabolites of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)","year":2006,"lang":"en","type":"article","venue":"Mutation research. Fundamental and molecular mechanisms of mutagenesis","topic":"Carcinogens and Genotoxicity Assessment","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; Université de Sherbrooke","funders":"Canadian Institutes of Health Research; Canada Research Chairs","keywords":"Chemistry; DNA damage; Comet assay; Methylation; Carcinogen; Adduct; Lysis; DNA; Biochemistry; Molecular biology; Enzyme; DNA methylation; Biology; Gene expression; Gene; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009889699,0.0002356709,0.0003414917,0.0003301932,0.0001899673,0.00003938388,0.0001868139,0.0001275655,0.00002053773],"category_scores_gemma":[0.00003164426,0.0001848661,0.0001012621,0.0004892029,0.0002916583,0.00001607045,0.0001419702,0.0001406302,3.827976e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006357226,"about_ca_system_score_gemma":0.00007633634,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001653424,"about_ca_topic_score_gemma":0.0004694109,"domain_scores_codex":[0.9976792,0.0005277962,0.000414042,0.0004273042,0.0005752341,0.0003764702],"domain_scores_gemma":[0.9988964,0.00006879699,0.000268946,0.0003276257,0.000363561,0.00007472842],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002484868,0.0002944891,0.0008595145,0.00006883054,0.0001246516,0.00004381068,0.00007410066,0.0006318741,0.9970469,0.000331422,0.000006504307,0.0002694234],"study_design_scores_gemma":[0.001139952,0.0006939161,0.007451358,0.00004109743,0.00008180256,0.00002596047,0.001785541,0.0004602191,0.9875365,0.0005658086,0.00002417865,0.0001936047],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9867783,0.000539072,0.0116313,0.00004211517,0.00001589281,0.0007166049,0.0002106328,0.000006914524,0.00005919749],"genre_scores_gemma":[0.9963932,0.00003855717,0.003164702,0.00002879327,0.00001952694,0.00005743232,0.0002104278,0.00003481883,0.00005251025],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009614958,"threshold_uncertainty_score":0.753862,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02311705667897821,"score_gpt":0.2978263900866031,"score_spread":0.2747093334076248,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}