{"id":"W2086971446","doi":"10.1016/j.mrfmmm.2006.04.005","title":"Formamidopyrimidine adducts are detected using the comet assay in human cells treated with reactive metabolites of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)","year":2006,"lang":"en","type":"article","venue":"Mutation research. Fundamental and molecular mechanisms of mutagenesis","topic":"Carcinogens and Genotoxicity Assessment","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; Université de Sherbrooke","funders":"Canadian Institutes of Health Research; Canada Research Chairs","keywords":"Chemistry; DNA damage; Comet assay; Methylation; Carcinogen; Adduct; Lysis; DNA; Biochemistry; Molecular biology; Enzyme; DNA methylation; Biology; Gene expression; Gene; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003318457,0.0007107086,0.0003186991,0.00067701,0.0002258449,0.0001965738,0.0002351497,0.0008330565,0.003531419],"category_scores_gemma":[0.0004592472,0.0002922899,0.0003524632,0.0004013373,0.0002853449,0.0002784307,0.0001685013,0.0005282231,0.0008448614],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001429072,"about_ca_system_score_gemma":0.0001335174,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005560491,"about_ca_topic_score_gemma":0.0007079719,"domain_scores_codex":[0.9997422,0.0000660895,0.00002422807,0.00006106895,0.0000749175,0.00003142119],"domain_scores_gemma":[0.9994699,0.0001467432,0.0001779029,0.00005597077,0.00007828724,0.00007122169],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001188668,0.00003230439,0.0005857989,0.00004800083,0.00001904175,0.00007919686,0.00007147794,0.00002017559,0.9978623,0.00007878562,0.00004502571,0.001039081],"study_design_scores_gemma":[0.00002421684,0.00128628,0.01535806,0.00001407235,0.00004449212,0.0008038009,0.00004850173,0.0002411386,0.9804258,0.00009505538,0.00165245,0.000006172399],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9771302,0.005559081,0.01136336,0.0002064327,0.0001709303,0.00008276345,0.001148697,0.0003517384,0.003986889],"genre_scores_gemma":[0.9799175,0.002368245,0.007940782,0.00008997905,0.00004241272,0.00007428453,0.002675368,0.00001434525,0.006877095],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003531419,"threshold_uncertainty_score":0.01181382,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02311705667897821,"score_gpt":0.2978263900866031,"score_spread":0.2747093334076248,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}