{"id":"W2087026799","doi":"10.1074/jbc.m109.072728","title":"Recruitment of cAMP-response Element-binding Protein and Histone Deacetylase Has Opposite Effects on Glucocorticoid Receptor Gene Transcription","year":2009,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier universitaire de Québec; Université Laval; Hôtel-Dieu de Québec","funders":"Harvard University","keywords":"CREB; Glucocorticoid receptor; Gene knockdown; CREB-binding protein; Histone deacetylase; Transcription (linguistics); Hormone response element; Response element; Histone; Gene; Transcription factor; Cyclic AMP Response Element-Binding Protein; Biology; Promoter; Chemistry; Glucocorticoid; Molecular biology; Gene expression; Endocrinology; Biochemistry; Genetics; Estrogen receptor; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002007544,0.0002668799,0.0003720451,0.0001809558,0.0001381276,0.0002796884,0.0002425286,0.0003197875,0.001284262],"category_scores_gemma":[0.0002407948,0.0001905888,0.0003752445,0.00009127675,0.0003744019,0.0002060984,0.0003334479,0.0005853078,0.0003457792],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003215696,"about_ca_system_score_gemma":0.0002562614,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007175612,"about_ca_topic_score_gemma":0.0010687,"domain_scores_codex":[0.9996529,0.00003133286,0.00001818726,0.00008865474,0.0001121986,0.00009662206],"domain_scores_gemma":[0.9998023,0.00002812873,0.00002967673,0.00001885993,0.00003779572,0.000083283],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001545335,0.00001227903,0.0004268852,0.00005509219,0.000005916307,0.00005228953,0.0000177325,0.00001597372,0.9974625,0.0001043906,0.00004414501,0.001648196],"study_design_scores_gemma":[0.00005741354,0.0004187048,0.03323046,0.0000262358,0.00003737075,0.0008018952,0.0001204547,0.0007136436,0.9597866,0.0001831356,0.004608831,0.00001522527],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9813201,0.009912677,0.003799267,0.000355165,0.0002477686,0.00003832992,0.0003103902,0.0001336572,0.003882494],"genre_scores_gemma":[0.9917428,0.002034666,0.002369775,0.0002504276,0.00005113024,0.00002906348,0.0003738426,0.00001935624,0.00312894],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001284262,"threshold_uncertainty_score":0.004296303,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02372989250870973,"score_gpt":0.2723228796272752,"score_spread":0.2485929871185655,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}