{"id":"W2087050026","doi":"10.1007/s11095-006-9033-2","title":"Screening of Lipid Carriers and Characterization of Drug-Polymer-Lipid Interactions for the Rational Design of Polymer-Lipid Hybrid Nanoparticles (PLN)","year":2006,"lang":"en","type":"article","venue":"Pharmaceutical Research","topic":"Drug Solubulity and Delivery Systems","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":89,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ontario Institute for Cancer Research; University of Toronto","funders":"","keywords":"Differential scanning calorimetry; Isothermal titration calorimetry; Chemistry; Solubility; Polymer; Chromatography; Organic chemistry; Physical chemistry; Thermodynamics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003764037,0.0002060832,0.0004149705,0.0002606697,0.0004789627,0.00003155772,0.0003669905,0.0001203531,0.0004722101],"category_scores_gemma":[0.0003473223,0.0001749847,0.0001462861,0.0004652635,0.001316113,0.0002668909,0.0001637185,0.0006867281,0.000007899483],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004800137,"about_ca_system_score_gemma":0.0002297595,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001688346,"about_ca_topic_score_gemma":0.00001139513,"domain_scores_codex":[0.9959821,0.00155396,0.0008924078,0.0003547152,0.0006125207,0.0006043379],"domain_scores_gemma":[0.9924875,0.006175056,0.0002814245,0.0002355915,0.0005893113,0.0002310834],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002411262,0.0004517476,0.003813922,0.0003038357,0.0002524243,0.000001933553,0.0005355389,0.0005860156,0.9749112,0.004117735,0.001629975,0.01098446],"study_design_scores_gemma":[0.001553192,0.000143298,0.0009551301,0.00005294616,0.0001441577,0.00001248978,0.0003367228,0.07495765,0.9046001,0.00009847693,0.01700219,0.0001435792],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.979443,0.001894504,0.0122743,0.002754174,0.0009045261,0.00162444,0.0006126578,0.00003489344,0.0004574762],"genre_scores_gemma":[0.9977335,0.0002790547,0.0001323677,0.0001576093,0.0006094345,0.0001528537,0.00006310285,0.00002745428,0.0008446593],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07437164,"threshold_uncertainty_score":0.7135669,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2593857849663053,"score_gpt":0.481860576938902,"score_spread":0.2224747919725967,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}