{"id":"W2087125825","doi":"10.1074/jbc.m413406200","title":"Rational Design of α-Helical Antimicrobial Peptides with Enhanced Activities and Specificity/Therapeutic Index","year":2005,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":598,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences","keywords":"Peptide; Antimicrobial; Chemistry; Amphiphile; Amino acid; Antimicrobial peptides; Residue (chemistry); Peptide sequence; Stereochemistry; Amide; Rational design; Biological activity; Biochemistry; Combinatorial chemistry; Organic chemistry; Biology; In vitro; Copolymer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002150615,0.0004563979,0.0003900385,0.00016009,0.00009861403,0.000320901,0.0002880025,0.0002721684,0.0004021732],"category_scores_gemma":[0.0001934733,0.0001765403,0.0001943628,0.0001928462,0.0001645032,0.0002741814,0.0002092251,0.0004627524,0.0003218956],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002392866,"about_ca_system_score_gemma":0.0002304716,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001511872,"about_ca_topic_score_gemma":0.0002245424,"domain_scores_codex":[0.9998889,0.00003080151,0.00001255141,0.00002518535,0.0000212692,0.00002134261],"domain_scores_gemma":[0.9999012,0.00001516103,0.00003847227,0.000005662507,0.00001428319,0.00002517281],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001846817,0.00006525317,0.0002234372,0.00009769183,0.00001322557,0.0001366689,0.00001661159,0.002548925,0.9896188,0.0002559583,0.00003732665,0.006801466],"study_design_scores_gemma":[0.0001347055,0.001478891,0.001021802,0.00002255026,0.00004768753,0.0005179769,0.0000302826,0.00790297,0.9830221,0.0001761965,0.005623345,0.00002148357],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9724078,0.004389018,0.02027471,0.0001023443,0.0000343778,0.0002270202,0.0001517374,0.0001101071,0.002302737],"genre_scores_gemma":[0.9677212,0.002573603,0.02839158,0.0001334547,0.00002025306,0.0000925919,0.0002096074,0.00003431809,0.0008233344],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004563979,"threshold_uncertainty_score":0.001736104,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02098823592905711,"score_gpt":0.2308569610757556,"score_spread":0.2098687251466985,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}