{"id":"W2087130093","doi":"10.1016/j.bmc.2007.12.022","title":"Synthesis and cytotoxic activity of diosgenyl saponin analogues","year":2007,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Phytochemical Studies and Bioactivities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":false,"ca_institutions":"NOSM University; Thunder Bay Regional Health Sciences Centre; Lakehead University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Saponin; Cytotoxic T cell; Stereochemistry; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002616269,0.0001905326,0.0002649444,0.00001577434,0.00006615411,0.000005711438,0.0001495059,0.0001930966,0.00004310478],"category_scores_gemma":[0.0002782345,0.0001609122,0.00007451101,0.0001018344,0.0003621339,0.000003469893,0.0001532861,0.0001142292,0.000001058447],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002438816,"about_ca_system_score_gemma":0.00004494608,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004956218,"about_ca_topic_score_gemma":0.00001386623,"domain_scores_codex":[0.9989822,0.00001306123,0.0002025479,0.0003253456,0.0001887306,0.0002881068],"domain_scores_gemma":[0.9993897,0.00006722858,0.0001190406,0.0002359234,0.00005217612,0.0001358973],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001581257,0.0000684986,0.001955818,0.0001110647,0.00008822342,0.000005211067,0.00002140415,2.142643e-8,0.9926017,0.000002451153,0.0003230754,0.004664411],"study_design_scores_gemma":[0.0002346568,0.00008498202,0.01265842,0.00004121907,0.00004438446,0.00003813346,0.0002670972,0.000001215064,0.9845445,0.00001496738,0.001897304,0.0001731689],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958148,0.002055821,0.0002107924,0.0001094241,0.00004086561,0.00008401628,0.00002848898,0.00001325077,0.001642569],"genre_scores_gemma":[0.9989782,0.0003258869,0.00008657658,0.00005636089,0.000368179,0.000009025545,0.00001487166,0.00001554982,0.0001453647],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0107026,"threshold_uncertainty_score":0.656181,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009776346925200241,"score_gpt":0.2378680160333726,"score_spread":0.2280916691081724,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}