{"id":"W2087130669","doi":"10.1038/sj.bjp.0705654","title":"Histamine‐induced inhibition of leukotriene biosynthesis in human neutrophils: involvement of the H<sub>2</sub> receptor and cAMP","year":2004,"lang":"en","type":"article","venue":"British Journal of Pharmacology","topic":"Mast cells and histamine","field":"Immunology and Microbiology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Institut universitaire de cardiologie et de pneumologie de Québec; Centre hospitalier de l'Université Laval","funders":"Canadian Institutes of Health Research; Arthritis Society","keywords":"Histamine; Histamine H1 receptor; Histamine receptor; Dimaprit; Histamine H2 receptor; Leukotriene; Histamine H4 receptor; Cimetidine; Histamine N-methyltransferase; Autacoid; Biosynthesis; Pharmacology; Cromolyn Sodium; Endocrinology; Chemistry; Biology; Internal medicine; Receptor; Biochemistry; Immunology; Medicine; Antagonist; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003327828,0.0005603093,0.0004335057,0.0001396256,0.0001414876,0.0002089042,0.0002224361,0.0003293636,0.001488952],"category_scores_gemma":[0.0001831602,0.0001226534,0.0003078698,0.00009232292,0.0001957478,0.0001398831,0.0002301705,0.0004119449,0.0004870029],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002084257,"about_ca_system_score_gemma":0.0002287975,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008298608,"about_ca_topic_score_gemma":0.001343678,"domain_scores_codex":[0.9997526,0.00008453079,0.00003463428,0.00002348661,0.00004889072,0.00005589868],"domain_scores_gemma":[0.9999502,0.00001156357,0.00001157681,0.000006685831,0.000007704803,0.00001224323],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001066806,0.00008685136,0.0001451986,0.0001718911,0.00001502174,0.0001626616,0.0000296811,0.00004536636,0.9936292,0.00007330292,0.0001339144,0.004440096],"study_design_scores_gemma":[0.0003220138,0.002484974,0.01585965,0.0000236501,0.00005924482,0.0006289002,0.00003342758,0.000732372,0.974221,0.00006815454,0.005557882,0.00000872855],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9567348,0.03327487,0.004653438,0.0005749739,0.0002275566,0.0002508514,0.0007592941,0.000124138,0.003399962],"genre_scores_gemma":[0.9842244,0.00951463,0.002671061,0.0002792301,0.0001086253,0.0001910636,0.001034469,0.00001622157,0.001960332],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001488952,"threshold_uncertainty_score":0.004981041,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01135512828878723,"score_gpt":0.2277860435727949,"score_spread":0.2164309152840077,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}