{"id":"W2087146189","doi":"10.1158/1078-0432.ccr-1131-03","title":"<b> <i>In Vitro</i> </b> and <b> <i>in Vivo</i> </b> Characterization of Doxorubicin and Vincristine Coencapsulated within Liposomes through Use of Transition Metal Ion Complexation and pH Gradient Loading","year":2004,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Nanoparticle-Based Drug Delivery","field":"Materials Science","cited_by":107,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Stemcell Technologies; BC Cancer Agency","funders":"","keywords":"In vivo; Vincristine; In vitro; Liposome; Doxorubicin; Chemistry; Characterization (materials science); Biophysics; Materials science; Nanotechnology; Biochemistry; Medicine; Biology; Chemotherapy; Internal medicine; Cyclophosphamide","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003291401,0.0003481023,0.0001735076,0.0002236589,0.00009942986,0.0002760229,0.0001318698,0.0002743689,0.0006747176],"category_scores_gemma":[0.0002372267,0.0001462267,0.000161782,0.0001266686,0.0002262816,0.000159781,0.00009689062,0.0003203548,0.00030907],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002934137,"about_ca_system_score_gemma":0.0001865862,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00170149,"about_ca_topic_score_gemma":0.001256193,"domain_scores_codex":[0.9998119,0.00004891303,0.00001951939,0.00004312761,0.000042772,0.00003366597],"domain_scores_gemma":[0.9997469,0.00007711854,0.00007042111,0.00001979207,0.00005716183,0.00002854069],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007950338,0.000009608737,0.00007884557,0.00002137243,0.000001870029,0.000009098202,0.000006448277,0.00006153883,0.999441,0.000009639943,0.000006611216,0.0002745212],"study_design_scores_gemma":[0.00000443457,0.0001494198,0.0008059322,0.000002330507,0.000005313846,0.00002154831,0.000004812725,0.0003362412,0.9984623,0.000003759051,0.0002022263,0.000001644],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911603,0.001831839,0.005135843,0.00006133219,0.00001441922,0.00005267733,0.0002733035,0.00006108993,0.001409131],"genre_scores_gemma":[0.993048,0.0009103091,0.003975193,0.00003347826,0.000007526192,0.00004162477,0.0004203313,0.00003150867,0.001532136],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00170149,"threshold_uncertainty_score":0.00338316,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1127490479998894,"score_gpt":0.3893579564175797,"score_spread":0.2766089084176903,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}