{"id":"W2087154861","doi":"10.1016/j.brainres.2006.07.041","title":"Mice with targeted disruption of neurofilament light subunit display formation of protein aggregation in motoneurons and downregulation of complement receptor type 3 α subunit in microglia in the spinal cord at their earlier age: A possible feature in pre-clinical development of neurodegenerative diseases","year":2006,"lang":"en","type":"article","venue":"Brain Research","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"Robarts Clinical Trials; Western University","funders":"National Medical Research Council","keywords":"Neurofilament; Microglia; Integrin alpha M; Spinal cord; Protein subunit; Lumbar Spinal Cord; Downregulation and upregulation; Biology; Cell biology; Neuropil; Pathology; Receptor; Neuroscience; Central nervous system; Immunohistochemistry; Immunology; Inflammation; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001733723,0.000999097,0.0004757346,0.001276819,0.0004037907,0.0004512848,0.000463616,0.001116193,0.003598301],"category_scores_gemma":[0.0001911245,0.0004392804,0.0004339404,0.0003385697,0.0006869127,0.0004120268,0.0004144313,0.00129603,0.0009390971],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004507141,"about_ca_system_score_gemma":0.0002652999,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008634576,"about_ca_topic_score_gemma":0.001805997,"domain_scores_codex":[0.9997448,0.00002067862,0.00003240666,0.00008468837,0.00005099723,0.00006634657],"domain_scores_gemma":[0.9994186,0.0000438167,0.0002938191,0.00003953227,0.00003334524,0.0001708512],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002050618,0.00004904596,0.000268263,0.00001941205,0.0000103322,0.0003750601,0.00003654417,0.00002208774,0.9983522,0.0002082247,0.0000537756,0.0003999842],"study_design_scores_gemma":[0.0001238275,0.0007604807,0.03721542,0.0000303355,0.0001051759,0.005136315,0.0001864242,0.0006325619,0.9515194,0.0005018811,0.003756092,0.0000321345],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928087,0.0006687345,0.003641895,0.0002610703,0.00007690649,0.00004254448,0.001098925,0.0002620019,0.00113922],"genre_scores_gemma":[0.9845064,0.0007955765,0.0030282,0.0001589525,0.00003606331,0.00008868625,0.001204888,0.0001814265,0.009999742],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003598301,"threshold_uncertainty_score":0.01203752,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07851374033176399,"score_gpt":0.361267506554785,"score_spread":0.282753766223021,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}