{"id":"W2087186233","doi":"10.1089/ars.2005.7.1014","title":"H <sub>2</sub> O <sub>2</sub> -Induced Phosphorylation of ERK1/2 and PKB Requires Tyrosine Kinase Activity of Insulin Receptor and c-Src","year":2005,"lang":"en","type":"article","venue":"Antioxidants and Redox Signaling","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôtel-Dieu de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"Proto-oncogene tyrosine-protein kinase Src; Tyrosine kinase; Phosphorylation; Protein kinase B; Receptor tyrosine kinase; Kinase; Insulin receptor; Insulin; Cell biology; Chemistry; Receptor; Endocrinology; Internal medicine; Cancer research; Biology; Biochemistry; Medicine; Insulin resistance","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004430306,0.0002540414,0.0003566293,0.0001209753,0.0001585544,0.00003367045,0.00007086439,0.0002574309,0.000005105558],"category_scores_gemma":[0.0001095394,0.000241275,0.00007893952,0.0001720503,0.0001931867,0.00004105197,0.0001111047,0.0001264224,8.507537e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001227681,"about_ca_system_score_gemma":0.00006027906,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002599842,"about_ca_topic_score_gemma":0.00001446939,"domain_scores_codex":[0.998514,0.00009875417,0.0004496754,0.0004759278,0.0002059676,0.0002556534],"domain_scores_gemma":[0.9990822,0.00003766464,0.0003683843,0.0002201769,0.0001611005,0.0001304391],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002427706,0.00009029183,0.0005922619,0.0001224722,0.00005600185,0.000002019783,0.00009380856,0.00005629974,0.9009761,0.00006709129,0.00002062993,0.0976803],"study_design_scores_gemma":[0.001084677,0.000261524,0.00592589,0.0002466456,0.00005065274,0.00001421793,0.00005091147,0.000704479,0.9911581,0.00006992549,0.0001591493,0.0002738618],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928262,0.005660155,0.0009736216,0.0001134043,0.00005460605,0.0002909928,0.00003704339,0.00001615769,0.00002785536],"genre_scores_gemma":[0.9960933,0.002920664,0.0006820994,0.00004845074,0.0001725197,0.000008199418,0.00003728596,0.00002983743,0.000007635001],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09740644,"threshold_uncertainty_score":0.9838907,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01054803978378856,"score_gpt":0.2330142984818055,"score_spread":0.2224662586980169,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}