{"id":"W2087192577","doi":"10.1371/journal.pgen.1004648","title":"Genome-Wide Discovery of Drug-Dependent Human Liver Regulatory Elements","year":2014,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Center for Advancing Translational Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; National Human Genome Research Institute; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Canadian Institutes of Health Research; National Institutes of Health; Oak Ridge Institute for Science and Education","keywords":"Pregnane X receptor; Biology; Enhancer; Genetics; Drug metabolism; Gene; Computational biology; Genome-wide association study; CYP3A4; Transcription factor; Single-nucleotide polymorphism; Cytochrome P450; Drug; Nuclear receptor; Pharmacology; Genotype; Biochemistry; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003027935,0.0001641779,0.0004845843,0.0004986908,0.0001577696,0.0002720293,0.0001678946,0.0002531829,0.00171246],"category_scores_gemma":[0.000404485,0.0001998716,0.0005460925,0.0007129798,0.0001366349,0.00006219386,0.0002270384,0.0003633058,0.0002649571],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001157967,"about_ca_system_score_gemma":0.0002141332,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001607434,"about_ca_topic_score_gemma":0.003539882,"domain_scores_codex":[0.9997107,0.00003380447,0.00001431562,0.0001630555,0.00004284009,0.00003531738],"domain_scores_gemma":[0.9997483,0.0001246781,0.00005125026,0.00002463751,0.00002070652,0.00003045322],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002244973,0.0002049813,0.4120195,0.0007512168,0.001982894,0.002449959,0.0004635009,0.002075877,0.5211632,0.001149988,0.003253837,0.05223997],"study_design_scores_gemma":[0.0001022268,0.0001401443,0.9775997,0.00002883543,0.0004561771,0.001274822,0.0000835361,0.002202035,0.0121142,0.0003260281,0.00564859,0.00002369869],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9876391,0.002185104,0.002983426,0.0001274356,0.0000163172,0.00002826828,0.005957213,0.00007766259,0.0009854828],"genre_scores_gemma":[0.9883056,0.0005604025,0.002568162,0.000220217,0.00002074165,0.00003212391,0.007548479,0.00003410577,0.0007101674],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00171246,"threshold_uncertainty_score":0.005728781,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07357397746529869,"score_gpt":0.3671907453405217,"score_spread":0.293616767875223,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}