{"id":"W2087226517","doi":"10.2353/ajpath.2007.061043","title":"Neutrophil Elastase Converts Human Immature Dendritic Cells into Transforming Growth Factor-β1-Secreting Cells and Reduces Allostimulatory Ability","year":2007,"lang":"en","type":"article","venue":"American Journal Of Pathology","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":58,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University","funders":"Agencia Nacional de Promoción Científica y Tecnológica; National Institutes of Health; National Institute of Dental and Craniofacial Research; Secretaría de Ciencia y Técnica, Universidad de Buenos Aires; Fundación Florencio Fiorini","keywords":"Elastase; Immunology; Neutrophil elastase; Biology; Cell biology; Dendritic cell; Transforming growth factor; Growth factor; Inflammation; Immune system; Receptor; Enzyme; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001111438,0.0002383194,0.0005931529,0.0002957014,0.0002521991,0.00001559771,0.0002083844,0.0002229378,0.00008190508],"category_scores_gemma":[0.00009443657,0.0002095669,0.0001584765,0.0001415731,0.001006915,0.0002201179,0.00004275696,0.000707984,0.00001765121],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007399508,"about_ca_system_score_gemma":0.00008506517,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000045523,"about_ca_topic_score_gemma":0.000006224868,"domain_scores_codex":[0.9977937,0.0005819919,0.0008598057,0.0002442122,0.00006622267,0.0004540169],"domain_scores_gemma":[0.9984151,0.0004692418,0.0006650537,0.0001640343,0.00021416,0.00007241833],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007409169,0.00005899663,0.0007481788,0.0000280964,0.00008149045,0.0003210843,0.003915677,0.000003989459,0.9825131,0.00007328321,0.00002931948,0.01148581],"study_design_scores_gemma":[0.001131618,0.0015289,0.01704219,0.00006230432,0.00008001106,0.001781927,0.00301301,0.00000139899,0.9743334,0.0002198874,0.0005696016,0.0002357458],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968504,0.001395675,0.000795997,0.0001662203,0.0005656248,0.0001290293,0.000007373021,0.00001966688,0.0000700312],"genre_scores_gemma":[0.9990053,0.0001885379,0.0004978442,0.0001729852,0.00007998223,0.000001224338,0.000008211912,0.00002146618,0.00002440743],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01629401,"threshold_uncertainty_score":0.8545892,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00556892603735479,"score_gpt":0.2413949902374775,"score_spread":0.2358260642001228,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}