{"id":"W2087264758","doi":"10.1523/jneurosci.1199-10.2010","title":"Bepridil and Amiodarone Simultaneously Target the Alzheimer's Disease  - and  -Secretase via Distinct Mechanisms","year":2010,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women's Health Research Institute","funders":"National Institute of General Medical Sciences; Deutsche Forschungsgemeinschaft; European Commission","keywords":"Bepridil; Endosome; Chemistry; Proteases; Amyloid precursor protein; Gamma secretase; In vivo; Amyloid precursor protein secretase; Neurodegeneration; Biochemistry; Pharmacology; Cell biology; Alzheimer's disease; Enzyme; Calcium; Biology; Receptor; Internal medicine; Disease; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001891798,0.000323984,0.0006486489,0.0001411028,0.0001273588,0.0004166811,0.0001956975,0.0003807051,0.0005961248],"category_scores_gemma":[0.0002177399,0.0001091321,0.0001807894,0.00009649985,0.0002306078,0.0004208497,0.0002162214,0.0005621727,0.0002023041],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001690706,"about_ca_system_score_gemma":0.0001284637,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000779625,"about_ca_topic_score_gemma":0.0002267587,"domain_scores_codex":[0.9998453,0.00003886706,0.00001827906,0.00002647388,0.00004359618,0.00002751381],"domain_scores_gemma":[0.9998987,0.00003189303,0.0000290532,0.000009702421,0.00001118654,0.00001943967],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003861608,0.00005417103,0.0003122034,0.00006775636,0.0000140996,0.00013346,0.00001609958,0.0000595235,0.9947591,0.0002061652,0.00003168266,0.003959541],"study_design_scores_gemma":[0.0001564623,0.001948489,0.002704381,0.000006354612,0.00004861777,0.0009462794,0.00001912357,0.0005752111,0.9906276,0.0001392543,0.002822202,0.0000059698],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893566,0.006393528,0.002108438,0.0002125739,0.0000408555,0.00004841856,0.00007337968,0.0000322667,0.001734057],"genre_scores_gemma":[0.9933059,0.002632355,0.002977642,0.0001548281,0.00004263501,0.00004351689,0.00008203737,0.000006395042,0.0007547326],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006486489,"threshold_uncertainty_score":0.001994252,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02166144851876854,"score_gpt":0.295836945767941,"score_spread":0.2741754972491725,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}