{"id":"W2087273774","doi":"10.1371/journal.ppat.1000532","title":"Hsp90 Governs Echinocandin Resistance in the Pathogenic Yeast Candida albicans via Calcineurin","year":2009,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Heat shock proteins research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":362,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; National Institutes of Health; Burroughs Wellcome Fund; University of Toronto; National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada","keywords":"Calcineurin; Echinocandin; Candida albicans; Echinocandins; Hsp90; Corpus albicans; Biology; Microbiology; Antifungal drug; Drug resistance; Heat shock protein; Biochemistry; Fluconazole; Medicine; Transplantation; Gene; Caspofungin; Antifungal","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00042589,0.0002302604,0.0002049337,0.0000718732,0.0001322716,0.00003911669,0.000562064,0.0001725337,0.00005518472],"category_scores_gemma":[0.0002175777,0.0001810456,0.0001183272,0.0003207871,0.00006792651,0.000005364505,0.00008250766,0.0003056916,0.00004357341],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007375933,"about_ca_system_score_gemma":0.0001554072,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007382065,"about_ca_topic_score_gemma":0.002467283,"domain_scores_codex":[0.9978045,0.0003134865,0.0002891535,0.00052711,0.0004564087,0.0006093934],"domain_scores_gemma":[0.9988881,0.00002282606,0.00005499101,0.0008331055,0.00006060986,0.0001403862],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001139171,0.0002143383,0.003048156,0.00001626016,0.0000181145,0.000155664,0.0002267509,0.000009274703,0.9938099,0.0001294778,0.0008959098,0.001362263],"study_design_scores_gemma":[0.003429274,0.001944165,0.2525588,0.0001669613,0.00009592204,0.0001783582,0.0004648746,0.0004191987,0.6291329,0.001256891,0.1087089,0.001643811],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899181,0.0007526729,0.0004315105,0.001438622,0.00003569882,0.0006461853,0.0002298945,0.00001941351,0.006527924],"genre_scores_gemma":[0.9969295,0.0001418305,0.000390547,0.0007616194,0.0002440747,0.00007842949,0.00009326921,0.00002918547,0.001331508],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.364677,"threshold_uncertainty_score":0.7382823,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01560354518132944,"score_gpt":0.2663859661204387,"score_spread":0.2507824209391093,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}