{"id":"W2087273774","doi":"10.1371/journal.ppat.1000532","title":"Hsp90 Governs Echinocandin Resistance in the Pathogenic Yeast Candida albicans via Calcineurin","year":2009,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Heat shock proteins research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":362,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; National Institutes of Health; Burroughs Wellcome Fund; University of Toronto; National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada","keywords":"Calcineurin; Echinocandin; Candida albicans; Echinocandins; Hsp90; Corpus albicans; Biology; Microbiology; Antifungal drug; Drug resistance; Heat shock protein; Biochemistry; Fluconazole; Medicine; Transplantation; Gene; Caspofungin; Antifungal","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000824749,0.0002234622,0.000148143,0.0001198523,0.0001512695,0.0003502723,0.0001711679,0.0002103798,0.000831136],"category_scores_gemma":[0.00007671774,0.00007467897,0.000169601,0.0001228713,0.0001690512,0.0001258316,0.0001849573,0.0004243412,0.0003008027],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002367404,"about_ca_system_score_gemma":0.0001809023,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007754505,"about_ca_topic_score_gemma":0.0008733124,"domain_scores_codex":[0.9999021,0.0000130002,0.000008366385,0.00002037061,0.00003110897,0.00002506556],"domain_scores_gemma":[0.9999474,0.000004908525,0.00001410639,0.000007071707,0.00001022202,0.00001632215],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002789856,0.00001055885,0.0001139491,0.00001372484,0.000002670869,0.00002979926,0.000004812118,0.00004052621,0.9990594,0.00009266216,0.00002724925,0.0005768845],"study_design_scores_gemma":[0.00001198816,0.0001035363,0.007878852,0.00000632513,0.00001554581,0.0003818075,0.00002963978,0.001026506,0.9880053,0.00008784206,0.002446961,0.000005694199],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927843,0.002352658,0.001913128,0.0001820412,0.00002860609,0.00002172251,0.0002939427,0.000119747,0.002303899],"genre_scores_gemma":[0.9975541,0.0006549812,0.0003695405,0.00004972199,0.000004342004,0.000006890294,0.0002031434,0.000009031072,0.001148183],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000831136,"threshold_uncertainty_score":0.002780378,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01560354518132944,"score_gpt":0.2663859661204387,"score_spread":0.2507824209391093,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}