{"id":"W2087280361","doi":"10.1210/jc.2011-0426","title":"Identification of Estrogen Response Element in the Aquaporin-2 Gene That Mediates Estrogen-Induced Cell Migration and Invasion in Human Endometrial Carcinoma","year":2011,"lang":"en","type":"article","venue":"The Journal of Clinical Endocrinology & Metabolism","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"National Key Research and Development Program of China; Zhejiang University; National Natural Science Foundation of China","keywords":"Aquaporin 2; Estrogen; Gene knockdown; Cell migration; Cancer research; Biology; Cell biology; Cell adhesion; Annexin; Internal medicine; Endocrinology; Cell culture; Cell; Water channel; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001043142,0.0001661265,0.0002022056,0.0001496288,0.0001212788,0.0001462456,0.0001083086,0.0002382244,0.001325532],"category_scores_gemma":[0.0001572939,0.00009910206,0.0002487259,0.0001297785,0.0001516668,0.0001031002,0.0001562564,0.0002336739,0.0002783341],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001707866,"about_ca_system_score_gemma":0.0001895399,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004511291,"about_ca_topic_score_gemma":0.0005481396,"domain_scores_codex":[0.9999466,0.000007374798,0.000004284388,0.00001218213,0.00001509509,0.00001437014],"domain_scores_gemma":[0.9999425,0.00001210853,0.00001524575,0.000006542711,0.00001101486,0.0000125743],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000324459,0.00003676401,0.004044608,0.0001345066,0.00001357228,0.0006609933,0.00006639937,0.0000593515,0.9923311,0.0001008164,0.0001212022,0.002106098],"study_design_scores_gemma":[0.0001978966,0.001202287,0.2340747,0.00006395522,0.0001359033,0.007000688,0.0005984415,0.002572854,0.7389133,0.0003045374,0.01490716,0.00002826174],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949425,0.002290699,0.001475994,0.0001321001,0.00003091304,0.0000342375,0.0003354826,0.00003099712,0.0007271116],"genre_scores_gemma":[0.9949767,0.001089401,0.001690245,0.0001085643,0.00001141516,0.00004722212,0.0006107552,0.000006352936,0.001459274],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001325532,"threshold_uncertainty_score":0.004434288,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06959131554448914,"score_gpt":0.325982748129783,"score_spread":0.2563914325852938,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}