{"id":"W2087292186","doi":"10.1016/j.jalz.2012.05.2088","title":"P3‐414: Evaluation of a novel caspase‐6 inhibitor as a potential treatment for Alzheimer's disease","year":2012,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Machine Learning in Bioinformatics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"New World Laboratories; McGill University","funders":"","keywords":"Caspase; Caspase 3; Molecular biology; Pharmacology; Cell culture; Apoptosis; Caspase-9; Recombinant DNA; Biology; Chemistry; Biochemistry; Programmed cell death; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003266129,0.0006546311,0.0005879872,0.0005109746,0.0002635359,0.0004192816,0.0004656363,0.0006671813,0.002629705],"category_scores_gemma":[0.0001356409,0.0001679002,0.0005078701,0.0003991701,0.0002254172,0.0003807765,0.0001972824,0.0009224052,0.0004854866],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002404119,"about_ca_system_score_gemma":0.0004383631,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007429215,"about_ca_topic_score_gemma":0.001235648,"domain_scores_codex":[0.9999002,0.00002241745,0.000009966625,0.00001853404,0.0000271372,0.00002168399],"domain_scores_gemma":[0.9999446,0.000008502485,0.000008715961,0.000003975309,0.00001219549,0.00002213886],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005044546,0.005412033,0.0004789433,0.001623314,0.0002053156,0.001023052,0.0001262029,0.001204073,0.907743,0.0006495996,0.001692412,0.07479752],"study_design_scores_gemma":[0.006805289,0.1080916,0.006929211,0.0001949194,0.0006178937,0.003737555,0.0001267123,0.004230962,0.827827,0.0004737921,0.04088448,0.00008060801],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9563261,0.02911574,0.004663112,0.0005401216,0.0002926795,0.0009156098,0.001199119,0.0002486259,0.006698936],"genre_scores_gemma":[0.9516429,0.02875131,0.008368492,0.0004023574,0.0001196388,0.0005904079,0.001783359,0.00005022721,0.008291242],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002629705,"threshold_uncertainty_score":0.008797228,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04054360114923575,"score_gpt":0.3275515882479689,"score_spread":0.2870079870987331,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}