{"id":"W2087314182","doi":"10.1007/s00044-013-0879-7","title":"Synthesis, molecular docking and antiviral screening of novel N′-substitutedbenzylidene-2-(4-methyl-5,5-dioxido-3-phenylbenzo[e]pyrazolo[4,3-c][1,2]thiazin-1(4H)-yl)acetohydrazides","year":2013,"lang":"en","type":"article","venue":"Medicinal Chemistry Research","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"University of Karachi","keywords":"Human immunodeficiency virus (HIV); Chemistry; EC50; Cytotoxic T cell; Reverse transcriptase; Docking (animal); Stereochemistry; In vitro; Molecular biology; Biochemistry; Virology; Biology; Gene; RNA; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001751052,0.0004471699,0.0008940473,0.0003418478,0.0002810201,0.00007759252,0.0003511785,0.0003009255,0.0006087395],"category_scores_gemma":[0.001765454,0.0003748267,0.0001627545,0.0008186934,0.0008898532,0.0002195001,0.0003255648,0.0009656737,0.00005056724],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001739614,"about_ca_system_score_gemma":0.0004016527,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002931331,"about_ca_topic_score_gemma":0.00000596056,"domain_scores_codex":[0.9953851,0.0001139817,0.0007327581,0.0008072155,0.001909689,0.001051281],"domain_scores_gemma":[0.9971039,0.0007948884,0.0001674511,0.0006587139,0.0007021998,0.0005728205],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002021436,0.0004053652,0.02512553,0.001049557,0.0003736677,0.0003905837,0.0006071274,0.00001263948,0.9585003,0.00007650375,0.001184131,0.01207245],"study_design_scores_gemma":[0.002764959,0.0001257521,0.008425859,0.00186962,0.0001973802,0.0002627523,0.001820671,0.001655105,0.9811004,0.0001052304,0.001295726,0.0003765396],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9823738,0.002548151,0.0003926633,0.003181255,0.00004305781,0.0007354144,0.00001158213,0.00008055173,0.01063353],"genre_scores_gemma":[0.9911552,0.0002736047,0.005221364,0.00005884998,0.0002225767,0.0001862431,0.00004633439,0.00006467421,0.002771117],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0226001,"threshold_uncertainty_score":0.9998704,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05432034330679223,"score_gpt":0.3502299735932986,"score_spread":0.2959096302865064,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}