{"id":"W2087314182","doi":"10.1007/s00044-013-0879-7","title":"Synthesis, molecular docking and antiviral screening of novel N′-substitutedbenzylidene-2-(4-methyl-5,5-dioxido-3-phenylbenzo[e]pyrazolo[4,3-c][1,2]thiazin-1(4H)-yl)acetohydrazides","year":2013,"lang":"en","type":"article","venue":"Medicinal Chemistry Research","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"University of Karachi","keywords":"Human immunodeficiency virus (HIV); Chemistry; EC50; Cytotoxic T cell; Reverse transcriptase; Docking (animal); Stereochemistry; In vitro; Molecular biology; Biochemistry; Virology; Biology; Gene; RNA; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000112972,0.000444683,0.0005230129,0.0002296521,0.000171311,0.0002043662,0.0005967919,0.0001657925,0.002072789],"category_scores_gemma":[0.0001039788,0.000224082,0.0002846577,0.0002666194,0.0001197152,0.0001544145,0.0001724487,0.0003220239,0.0006009446],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000277184,"about_ca_system_score_gemma":0.0003309358,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001741534,"about_ca_topic_score_gemma":0.00414786,"domain_scores_codex":[0.9999478,0.000008536614,0.000003292485,0.00001001064,0.00001434835,0.00001601096],"domain_scores_gemma":[0.999975,0.000004017783,0.000005672893,0.000003264267,0.000004523118,0.000007518415],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001100136,0.000592529,0.001151161,0.0003806661,0.00009958426,0.0002813698,0.00004819417,0.01991108,0.9453156,0.0009587237,0.001039308,0.02912162],"study_design_scores_gemma":[0.0007760614,0.003061064,0.003968127,0.00003009185,0.0002047159,0.0003136011,0.00005554637,0.03866197,0.9416373,0.0001601214,0.0110863,0.00004499672],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9816402,0.002858866,0.007777003,0.0001836833,0.00005840157,0.0001812387,0.001264919,0.0003570856,0.005678621],"genre_scores_gemma":[0.9824104,0.002779798,0.009119692,0.00004556831,0.000008912636,0.00008542086,0.001783654,0.00001845151,0.00374804],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002072789,"threshold_uncertainty_score":0.006934166,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05432034330679223,"score_gpt":0.3502299735932986,"score_spread":0.2959096302865064,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}