{"id":"W2087323626","doi":"10.1093/eurjhf/hfp048","title":"Defective Peroxisomal Proliferators Activated Receptor Gamma Activity Due to Dominant-Negative Mutation Synergizes with Hypertension to Accelerate Cardiac Fibrosis in Mice","year":2009,"lang":"en","type":"article","venue":"European Journal of Heart Failure","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Northern British Columbia","funders":"Medical Research Council; Diabetes UK; British Heart Foundation; Wellcome Trust","keywords":"Internal medicine; Endocrinology; Medicine; Cardiac fibrosis; Fibrosis; Angiotensin II; Cardiac function curve; Peroxisome proliferator-activated receptor; Heart failure; Blood pressure; Insulin resistance; Receptor; Diabetes mellitus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006712581,0.000403509,0.0005769852,0.0003353288,0.0001519454,0.00009361139,0.0002517877,0.0001238135,0.00001471192],"category_scores_gemma":[0.0004297217,0.000322405,0.0001705446,0.0006350121,0.00005073189,0.00007670706,0.00007913871,0.000485391,0.00003601459],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001306575,"about_ca_system_score_gemma":0.0001947048,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001036823,"about_ca_topic_score_gemma":0.00001420029,"domain_scores_codex":[0.99706,0.001084348,0.0004983245,0.0005307601,0.0003576038,0.0004689352],"domain_scores_gemma":[0.9984101,0.00005076098,0.0003035334,0.0002515128,0.0005844419,0.000399669],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004233592,0.0001831563,0.001335136,0.00000980963,0.0001039668,0.00009935685,0.0005558251,0.0006870205,0.9857625,6.788432e-7,0.005132428,0.00189656],"study_design_scores_gemma":[0.001412318,0.004513358,0.01774632,0.000227422,0.00002897469,0.0002869601,0.0003954197,0.000004568495,0.9678952,0.000001717875,0.0070886,0.0003992127],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952725,0.00005873583,0.000353288,0.00346045,0.0001796995,0.0005860049,0.00002227934,0.000017122,0.0000499592],"genre_scores_gemma":[0.9896671,0.00001596733,0.009252971,0.0005447804,0.0003914605,0.00001082026,0.00001171784,0.00006926599,0.00003591738],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01786734,"threshold_uncertainty_score":0.9999228,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007115531023821503,"score_gpt":0.219711601086486,"score_spread":0.2125960700626645,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}