{"id":"W2087347895","doi":"10.1016/j.biochi.2006.03.004","title":"Copper(II) and manganese(III) complexes of N′-[(2-hydroxy phenyl) carbonothioyl] pyridine-2-carbohydrazide: novel therapeutic agents for cancer","year":2006,"lang":"en","type":"article","venue":"Biochimie","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan; Saskatchewan Cancer Agency","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Myristoylation; Apoptosis; Cytotoxicity; Proto-oncogene tyrosine-protein kinase Src; Cancer research; Cell growth; Ligand (biochemistry); Carbohydrazide; Growth inhibition; Signal transduction; Receptor; Biochemistry; Medicinal chemistry; Biology; Phosphorylation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001227718,0.0002028035,0.0002245321,0.00005003256,0.0001425144,0.00001735026,0.0001287052,0.0001467843,0.00001620496],"category_scores_gemma":[0.00001298958,0.0001913993,0.0001143375,0.00008701199,0.0001370434,0.00000454946,0.00008377906,0.0000467913,4.324708e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001544834,"about_ca_system_score_gemma":0.00005911158,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003643261,"about_ca_topic_score_gemma":0.0001150525,"domain_scores_codex":[0.9989701,0.00002003064,0.0002797839,0.0003477355,0.0001327123,0.0002496242],"domain_scores_gemma":[0.9994521,0.00001393076,0.0001412467,0.0002422647,0.00008900139,0.00006145794],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009623055,0.00008782371,0.0006871083,0.00006709526,0.00006627938,3.639738e-7,0.0000264124,0.0003899619,0.9958807,0.001507947,0.0007004138,0.0004896187],"study_design_scores_gemma":[0.001623942,0.0001493832,0.003017517,0.0000512508,0.00005679014,0.000004483603,0.00001823775,0.002029815,0.9614098,0.0003315208,0.03103924,0.0002680012],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904458,0.004897126,0.003118118,0.0003474508,0.0001060311,0.000529555,0.0001378591,0.00002075039,0.000397299],"genre_scores_gemma":[0.9978918,0.00009565269,0.000647219,0.000329169,0.0002447298,0.00008930402,0.0001966296,0.00003395996,0.0004714937],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03447092,"threshold_uncertainty_score":0.7805036,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02097439409455522,"score_gpt":0.2720972434087907,"score_spread":0.2511228493142355,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}