{"id":"W2087347895","doi":"10.1016/j.biochi.2006.03.004","title":"Copper(II) and manganese(III) complexes of N′-[(2-hydroxy phenyl) carbonothioyl] pyridine-2-carbohydrazide: novel therapeutic agents for cancer","year":2006,"lang":"en","type":"article","venue":"Biochimie","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan; Saskatchewan Cancer Agency","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Myristoylation; Apoptosis; Cytotoxicity; Proto-oncogene tyrosine-protein kinase Src; Cancer research; Cell growth; Ligand (biochemistry); Carbohydrazide; Growth inhibition; Signal transduction; Receptor; Biochemistry; Medicinal chemistry; Biology; Phosphorylation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001246939,0.0002081342,0.0001941909,0.0001225734,0.0001354625,0.0001934133,0.0003633867,0.0002023774,0.001197193],"category_scores_gemma":[0.0001128506,0.0001265536,0.00007850389,0.0001194847,0.0001574391,0.000128719,0.0001276032,0.0002269014,0.0002008754],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004857926,"about_ca_system_score_gemma":0.0001910884,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002148431,"about_ca_topic_score_gemma":0.00298532,"domain_scores_codex":[0.999956,0.000008613982,0.000001937426,0.000007210462,0.000008798909,0.00001745858],"domain_scores_gemma":[0.9999766,0.000003978768,0.00000512331,0.000002604226,0.000003002879,0.000008670112],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00134145,0.00007394401,0.0002603976,0.0001976474,0.00002335537,0.0001680809,0.00004133123,0.0005024588,0.9833113,0.001696966,0.001679308,0.01070376],"study_design_scores_gemma":[0.0001821185,0.0005524054,0.0007517787,0.000007315969,0.00004192597,0.0003195958,0.00002109389,0.001552392,0.984795,0.0001480884,0.01162047,0.000007911747],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9737848,0.008339053,0.006267282,0.0004008353,0.0001930233,0.00005881576,0.0001461553,0.0005589509,0.01025105],"genre_scores_gemma":[0.9907072,0.001678446,0.001277286,0.00005039472,0.00002319111,0.0000188399,0.0001055404,0.00002109252,0.006118056],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002148431,"threshold_uncertainty_score":0.004271865,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02097439409455522,"score_gpt":0.2720972434087907,"score_spread":0.2511228493142355,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}