{"id":"W2087353276","doi":"10.1039/c3ob42548g","title":"Synthesis and antimalarial activity of prodigiosenes","year":2014,"lang":"en","type":"article","venue":"Organic & Biomolecular Chemistry","topic":"Microbial Metabolism and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"Acadia University; Dalhousie University","funders":"","keywords":"Chemistry; Plasmodium falciparum; Tin; Stereochemistry; Alkyl; Ligand (biochemistry); Ring (chemistry); IC50; Nitrogen atom; Cobalt; Zinc; Combinatorial chemistry; Medicinal chemistry; In vitro; Organic chemistry; Receptor; Biochemistry; Malaria","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008413216,0.0002575512,0.0002143156,0.0001595163,0.00009748673,0.0002199628,0.0002170112,0.000172654,0.001079678],"category_scores_gemma":[0.0001373288,0.00009803619,0.0001573102,0.0001706025,0.0001291091,0.0001241,0.0001396527,0.0002835177,0.0002342542],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002611007,"about_ca_system_score_gemma":0.0002025274,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006460192,"about_ca_topic_score_gemma":0.001198964,"domain_scores_codex":[0.9999342,0.0000100892,0.000006632215,0.00001596418,0.00001846148,0.00001456045],"domain_scores_gemma":[0.9999391,0.000007336316,0.00001399747,0.000008340078,0.00001272369,0.00001856066],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001229209,0.00001755093,0.000103835,0.0001021869,0.000006746627,0.0000975826,0.00001672169,0.0003295018,0.9947947,0.0002991677,0.00002672303,0.004082306],"study_design_scores_gemma":[0.00003919511,0.00065937,0.000795447,0.000009502818,0.00002417833,0.0003536282,0.00001718772,0.0002558886,0.9894521,0.0000554767,0.00832982,0.000008330363],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9860622,0.002971458,0.005081402,0.00007022968,0.00004452251,0.0001187912,0.0004280247,0.00007069698,0.005152557],"genre_scores_gemma":[0.9877177,0.001712553,0.006988877,0.00003666941,0.000009674792,0.00004064737,0.000412888,0.00001507979,0.003065797],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001079678,"threshold_uncertainty_score":0.003611863,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003607037510521831,"score_gpt":0.2041299049166394,"score_spread":0.2005228674061175,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}