{"id":"W2087353276","doi":"10.1039/c3ob42548g","title":"Synthesis and antimalarial activity of prodigiosenes","year":2014,"lang":"en","type":"article","venue":"Organic & Biomolecular Chemistry","topic":"Microbial Metabolism and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"Acadia University; Dalhousie University","funders":"","keywords":"Chemistry; Plasmodium falciparum; Tin; Stereochemistry; Alkyl; Ligand (biochemistry); Ring (chemistry); IC50; Nitrogen atom; Cobalt; Zinc; Combinatorial chemistry; Medicinal chemistry; In vitro; Organic chemistry; Receptor; Biochemistry; Malaria","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001126351,0.000137574,0.000164886,0.00001201441,0.00005163572,0.00001523319,0.0001572346,0.00014678,0.00004447616],"category_scores_gemma":[0.0001920567,0.00013854,0.0000612921,0.00009204121,0.0001278959,0.000002625935,0.0001245944,0.0000483484,0.000003853157],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003141847,"about_ca_system_score_gemma":0.000041598,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007054049,"about_ca_topic_score_gemma":9.915293e-7,"domain_scores_codex":[0.9992744,0.00002955013,0.000134736,0.0003317118,0.00007810101,0.000151535],"domain_scores_gemma":[0.9993702,0.000009980575,0.00009132587,0.0004089377,0.00005100483,0.0000685983],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001949469,0.00005835334,0.0001378525,0.00007314116,0.00002776104,3.850043e-7,0.00000542284,5.103275e-8,0.9970341,0.00003612395,0.0001276936,0.002479619],"study_design_scores_gemma":[0.0002189433,0.00001693864,0.0007959818,0.00001128119,0.00003975447,0.00001928505,0.000004838184,0.000009215186,0.990844,0.00002808685,0.00786249,0.0001491718],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9638919,0.000203991,0.03468718,0.0001235269,0.00002785049,0.00009331576,0.00002437332,0.00001306887,0.0009347984],"genre_scores_gemma":[0.998941,0.00009936271,0.0005980293,0.00003593395,0.0001608619,0.00001148609,0.00001643798,0.00002248841,0.0001143685],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03504913,"threshold_uncertainty_score":0.5649496,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003607037510521831,"score_gpt":0.2041299049166394,"score_spread":0.2005228674061175,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}